Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34

Elisabetta Bartolini; Kris Van Moer; Bassam Janji

doi:10.1080/2162402X.2024.2364958

Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34

Elisabetta Bartolini, Kris Van Moer, Bassam Janji^*

^*Corresponding author for this work

Tumor Immunotherapy and Microenvironment

Research output: Contribution to journal › Letter › peer-review

Abstract

We have recently demonstrated that inhibiting VPS34 enhances T-cell-recruiting chemokines through the activation of the cGAS/STING pathway using the STING agonist ADU-S100. Combining VPS34 inhibitors with ADU-S100 increased cytokine release and improved tumor control in mouse models, suggesting a potential synergy between VPS34 inhibition and therapies based on STING agonists.

Original language	English
Article number	2364958
Journal	OncoImmunology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2024.2364958
Publication status	Published - 11 Jun 2024

Keywords

Autophagy
CCL5
CD8 T cells
CXCL10
immunotherapy
melanoma
NK cells
PIK3C3
renal cell carcinoma
STING agonist
type I IFN response
VPS34

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10.1080/2162402X.2024.2364958Licence: CC BY

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title = "Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34",

abstract = "We have recently demonstrated that inhibiting VPS34 enhances T-cell-recruiting chemokines through the activation of the cGAS/STING pathway using the STING agonist ADU-S100. Combining VPS34 inhibitors with ADU-S100 increased cytokine release and improved tumor control in mouse models, suggesting a potential synergy between VPS34 inhibition and therapies based on STING agonists.",

keywords = "Autophagy, CCL5, CD8 T cells, CXCL10, immunotherapy, melanoma, NK cells, PIK3C3, renal cell carcinoma, STING agonist, type I IFN response, VPS34",

author = "Elisabetta Bartolini and {Van Moer}, Kris and Bassam Janji",

note = "Funding This work was supported by grants from Luxembourg National Research Fund (BRIDGES2020/BM/15412275/SMART COMBO) and Stiftelsen Cancera, Sweden Publisher Copyright: {\textcopyright} 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.",

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doi = "10.1080/2162402X.2024.2364958",

language = "English",

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TY - JOUR

T1 - Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34

AU - Bartolini, Elisabetta

AU - Van Moer, Kris

AU - Janji, Bassam

N1 - Funding This work was supported by grants from Luxembourg National Research Fund (BRIDGES2020/BM/15412275/SMART COMBO) and Stiftelsen Cancera, Sweden Publisher Copyright: © 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

PY - 2024/6/11

Y1 - 2024/6/11

N2 - We have recently demonstrated that inhibiting VPS34 enhances T-cell-recruiting chemokines through the activation of the cGAS/STING pathway using the STING agonist ADU-S100. Combining VPS34 inhibitors with ADU-S100 increased cytokine release and improved tumor control in mouse models, suggesting a potential synergy between VPS34 inhibition and therapies based on STING agonists.

AB - We have recently demonstrated that inhibiting VPS34 enhances T-cell-recruiting chemokines through the activation of the cGAS/STING pathway using the STING agonist ADU-S100. Combining VPS34 inhibitors with ADU-S100 increased cytokine release and improved tumor control in mouse models, suggesting a potential synergy between VPS34 inhibition and therapies based on STING agonists.

KW - Autophagy

KW - CCL5

KW - CD8 T cells

KW - CXCL10

KW - immunotherapy

KW - melanoma

KW - NK cells

KW - PIK3C3

KW - renal cell carcinoma

KW - STING agonist

KW - type I IFN response

KW - VPS34

UR - http://www.scopus.com/inward/record.url?scp=85195664979&partnerID=8YFLogxK

UR - https://pubmed.ncbi.nlm.nih.gov/38872753

U2 - 10.1080/2162402X.2024.2364958

DO - 10.1080/2162402X.2024.2364958

M3 - Letter

C2 - 38872753

AN - SCOPUS:85195664979

SN - 2162-4011

VL - 13

JO - OncoImmunology

JF - OncoImmunology

IS - 1

M1 - 2364958

ER -

Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34

Abstract

Keywords

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