Improved antiviral activity in vitro of ribavirin against measles virus after complexation with cyclodextrins

Nicolas Grancher*, Véronique Venard, Francine Kedzierewicz, Wim Ammerlaan, Chantal Finance, Claude P. Muller, Alain Le Faou

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    26 Citations (Scopus)

    Abstract

    Despite vaccination, measles remains a burden in both developed and developing countries and complications may necessitate an efficient therapy. Measles virus (MEV) is susceptible to ribavirin (RBV), but the use of this drug is limited by its toxicity. Cyclodextrins (CDs) can form complexes with numerous molecules, improving their bioavailability and their biological properties. We have evaluated in vitro the antiviral effects of complexes of RBV with α-, β- or γ-CD against two clade A laboratory strains of MEV (Edmonston and CAM/RB) grown on Vero cells. Complexation of RBV with α-CD or β-CD lead to a five-fold or a two-fold decrease in the 50% inhibitory concentration, respectively, against both MEV strains. In contrast, γ-CD complexation showed no modification.

    Original languageEnglish
    Pages (from-to)135-137
    Number of pages3
    JournalAntiviral Research
    Volume62
    Issue number3
    DOIs
    Publication statusPublished - Jun 2004

    Keywords

    • Antiviral activity
    • Cyclodextrins
    • Measles virus
    • Ribavirin

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