Improved antiviral activity in vitro of ribavirin against measles virus after complexation with cyclodextrins

Nicolas Grancher; Véronique Venard; Francine Kedzierewicz; Wim Ammerlaan; Chantal Finance; Claude P. Muller; Alain Le Faou

doi:10.1016/j.antiviral.2004.01.003

Improved antiviral activity in vitro of ribavirin against measles virus after complexation with cyclodextrins

Nicolas Grancher^*, Véronique Venard, Francine Kedzierewicz, Wim Ammerlaan, Chantal Finance, Claude P. Muller, Alain Le Faou

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Abstract

Despite vaccination, measles remains a burden in both developed and developing countries and complications may necessitate an efficient therapy. Measles virus (MEV) is susceptible to ribavirin (RBV), but the use of this drug is limited by its toxicity. Cyclodextrins (CDs) can form complexes with numerous molecules, improving their bioavailability and their biological properties. We have evaluated in vitro the antiviral effects of complexes of RBV with α-, β- or γ-CD against two clade A laboratory strains of MEV (Edmonston and CAM/RB) grown on Vero cells. Complexation of RBV with α-CD or β-CD lead to a five-fold or a two-fold decrease in the 50% inhibitory concentration, respectively, against both MEV strains. In contrast, γ-CD complexation showed no modification.

Original language	English
Pages (from-to)	135-137
Number of pages	3
Journal	Antiviral Research
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/j.antiviral.2004.01.003
Publication status	Published - Jun 2004

Keywords

Antiviral activity
Cyclodextrins
Measles virus
Ribavirin

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10.1016/j.antiviral.2004.01.003

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title = "Improved antiviral activity in vitro of ribavirin against measles virus after complexation with cyclodextrins",

abstract = "Despite vaccination, measles remains a burden in both developed and developing countries and complications may necessitate an efficient therapy. Measles virus (MEV) is susceptible to ribavirin (RBV), but the use of this drug is limited by its toxicity. Cyclodextrins (CDs) can form complexes with numerous molecules, improving their bioavailability and their biological properties. We have evaluated in vitro the antiviral effects of complexes of RBV with α-, β- or γ-CD against two clade A laboratory strains of MEV (Edmonston and CAM/RB) grown on Vero cells. Complexation of RBV with α-CD or β-CD lead to a five-fold or a two-fold decrease in the 50% inhibitory concentration, respectively, against both MEV strains. In contrast, γ-CD complexation showed no modification.",

keywords = "Antiviral activity, Cyclodextrins, Measles virus, Ribavirin",

author = "Nicolas Grancher and V{\'e}ronique Venard and Francine Kedzierewicz and Wim Ammerlaan and Chantal Finance and Muller, {Claude P.} and {Le Faou}, Alain",

note = "Funding Information: This research was supported by the Minist{\`e}re de la Culture, de l{\textquoteright}Enseignement Sup{\'e}rieur et de la Recherche of Luxembourg.",

year = "2004",

month = jun,

doi = "10.1016/j.antiviral.2004.01.003",

language = "English",

volume = "62",

pages = "135--137",

journal = "Antiviral Research",

issn = "0166-3542",

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T1 - Improved antiviral activity in vitro of ribavirin against measles virus after complexation with cyclodextrins

AU - Grancher, Nicolas

AU - Venard, Véronique

AU - Kedzierewicz, Francine

AU - Ammerlaan, Wim

AU - Finance, Chantal

AU - Muller, Claude P.

AU - Le Faou, Alain

N1 - Funding Information: This research was supported by the Ministère de la Culture, de l’Enseignement Supérieur et de la Recherche of Luxembourg.

PY - 2004/6

Y1 - 2004/6

N2 - Despite vaccination, measles remains a burden in both developed and developing countries and complications may necessitate an efficient therapy. Measles virus (MEV) is susceptible to ribavirin (RBV), but the use of this drug is limited by its toxicity. Cyclodextrins (CDs) can form complexes with numerous molecules, improving their bioavailability and their biological properties. We have evaluated in vitro the antiviral effects of complexes of RBV with α-, β- or γ-CD against two clade A laboratory strains of MEV (Edmonston and CAM/RB) grown on Vero cells. Complexation of RBV with α-CD or β-CD lead to a five-fold or a two-fold decrease in the 50% inhibitory concentration, respectively, against both MEV strains. In contrast, γ-CD complexation showed no modification.

AB - Despite vaccination, measles remains a burden in both developed and developing countries and complications may necessitate an efficient therapy. Measles virus (MEV) is susceptible to ribavirin (RBV), but the use of this drug is limited by its toxicity. Cyclodextrins (CDs) can form complexes with numerous molecules, improving their bioavailability and their biological properties. We have evaluated in vitro the antiviral effects of complexes of RBV with α-, β- or γ-CD against two clade A laboratory strains of MEV (Edmonston and CAM/RB) grown on Vero cells. Complexation of RBV with α-CD or β-CD lead to a five-fold or a two-fold decrease in the 50% inhibitory concentration, respectively, against both MEV strains. In contrast, γ-CD complexation showed no modification.

KW - Antiviral activity

KW - Cyclodextrins

KW - Measles virus

KW - Ribavirin

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U2 - 10.1016/j.antiviral.2004.01.003

DO - 10.1016/j.antiviral.2004.01.003

M3 - Article

C2 - 15130537

AN - SCOPUS:2342635857

SN - 0166-3542

VL - 62

SP - 135

EP - 137

JO - Antiviral Research

JF - Antiviral Research

IS - 3

ER -

Improved antiviral activity in vitro of ribavirin against measles virus after complexation with cyclodextrins

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Keywords

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