Impatto occupazionale ed ambientale dei nanotubi di carbonio, analisi della citotossicità su linee cellulari

L. Ghibelli; M. De Nicola; G. Somma; C. Cerella; M. D'Alessio; E. Romeo; A. Magrini; Antonio Bergamaschi

Impatto occupazionale ed ambientale dei nanotubi di carbonio, analisi della citotossicità su linee cellulari

Translated title of the contribution: Lack of direct cytotoxic effect of intracellular nanotubes

L. Ghibelli, M. De Nicola, G. Somma, C. Cerella, M. D'Alessio, E. Romeo, A. Magrini, Antonio Bergamaschi

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

Nanotubes have a great therapeutic potential due to their astounding physico-chemical features, the possibility to be funtionalised for ad hoc uses, and the specific interaction of nanotubes as such with life molecules (DNA and proteins). These features recommend a thorough toxicological study before widespread pharmaceutic use. We provide evidence that culture cells with phagocytic potential internalise multiwall nanotubes (10-50 nm average size). This is not accompanied by cytotoxicity in terms of induction of apoptosis or necrosis at the doses used (up to 125 μg/ml).

Translated title of the contribution	Lack of direct cytotoxic effect of intracellular nanotubes
Original language	Undefined/Unknown
Pages (from-to)	383-384
Number of pages	2
Journal	Giornale Italiano di Medicina del Lavoro ed Ergonomia
Volume	27
Issue number	3
Publication status	Published - Jul 2005
Externally published	Yes

Keywords

Apoptosis
Cytotoxic effect
Nanotubes

Cite this

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abstract = "Nanotubes have a great therapeutic potential due to their astounding physico-chemical features, the possibility to be funtionalised for ad hoc uses, and the specific interaction of nanotubes as such with life molecules (DNA and proteins). These features recommend a thorough toxicological study before widespread pharmaceutic use. We provide evidence that culture cells with phagocytic potential internalise multiwall nanotubes (10-50 nm average size). This is not accompanied by cytotoxicity in terms of induction of apoptosis or necrosis at the doses used (up to 125 μg/ml).",

keywords = "Apoptosis, Cytotoxic effect, Nanotubes",

author = "L. Ghibelli and {De Nicola}, M. and G. Somma and C. Cerella and M. D'Alessio and E. Romeo and A. Magrini and Antonio Bergamaschi",

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T1 - Impatto occupazionale ed ambientale dei nanotubi di carbonio, analisi della citotossicità su linee cellulari

AU - Ghibelli, L.

AU - De Nicola, M.

AU - Somma, G.

AU - Cerella, C.

AU - D'Alessio, M.

AU - Romeo, E.

AU - Magrini, A.

AU - Bergamaschi, Antonio

PY - 2005/7

Y1 - 2005/7

N2 - Nanotubes have a great therapeutic potential due to their astounding physico-chemical features, the possibility to be funtionalised for ad hoc uses, and the specific interaction of nanotubes as such with life molecules (DNA and proteins). These features recommend a thorough toxicological study before widespread pharmaceutic use. We provide evidence that culture cells with phagocytic potential internalise multiwall nanotubes (10-50 nm average size). This is not accompanied by cytotoxicity in terms of induction of apoptosis or necrosis at the doses used (up to 125 μg/ml).

AB - Nanotubes have a great therapeutic potential due to their astounding physico-chemical features, the possibility to be funtionalised for ad hoc uses, and the specific interaction of nanotubes as such with life molecules (DNA and proteins). These features recommend a thorough toxicological study before widespread pharmaceutic use. We provide evidence that culture cells with phagocytic potential internalise multiwall nanotubes (10-50 nm average size). This is not accompanied by cytotoxicity in terms of induction of apoptosis or necrosis at the doses used (up to 125 μg/ml).

KW - Apoptosis

KW - Cytotoxic effect

KW - Nanotubes

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AN - SCOPUS:26244443944

SN - 1592-7830

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JO - Giornale Italiano di Medicina del Lavoro ed Ergonomia

JF - Giornale Italiano di Medicina del Lavoro ed Ergonomia

IS - 3

ER -

Impatto occupazionale ed ambientale dei nanotubi di carbonio, analisi della citotossicità su linee cellulari

Abstract

Keywords

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