Impaired pituitary hormonal response to exhaustive exercise in overtrained endurance athletes

Axel Urhausen*, Holger H.W. Gabriel, Wilfried Kindermann

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

164 Citations (Scopus)

Abstract

The aim of the present prospective longitudinal study was to investigate the hormonal response in overtrained athletes at rest and during exercise consisting of a short-term exhaustive endurance test on a cycle ergometer at an intensity 10% above the individual anaerobic threshold. Over a period of 19 ± 1 months, 17 male endurance athletes (cyclists and triathletes; age 23.4 ± 1.6 yr: V̇O(2max) 61.2 ± 1.8 mL · min-1 · kg-1: means ± SEM) were examined five times on two separate days under standardized conditions. Short-term overtraining states (OT, N = 15) were primarily induced by an increase of frequency of high-intensive bouts of exercise or competitions without increase of the total amount of training. OT was compared with normal training states intraindividually (NS, N = 62). During OT, the time to exhaustion of the exercise test was significantly decreased by 27% on average. At rest and during exercise, the concentrations in plasma and the nocturnal excretion in urine of free epinephrine and norepinephrine were not significantly changed during OT. At physical rest, the concentrations of (free) testosterone, cortisol, luteinizing hormone, follicle-stimulating hormone, adrenocorticotropic hormone, growth hormone, and insulin during OT were comparable with those during NS. A significantly (P < 0.025) lower maximal exercise-reduced increase of the adrenocorticotropic hormone and growth hormone, as well as a trend for a decrease of cortisol (P = 0.060) and insulin (P = 0.036), was measured. The response of free catecholamines as well as the ergometric performance of an all-out 30-s test was unchanged. Serum urea, uric acid, ferritin, and activity of creatine kinase showed no differences between conditions. In conclusion, the results confrere the hypothesis of a hypothalamo-pituitary dysregulation during OT expressed by an impaired response of pituitary hormones to exhaustive short-endurance exercise.

Original languageEnglish
Pages (from-to)407-414
Number of pages8
JournalMedicine and Science in Sports and Exercise
Volume30
Issue number3
DOIs
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • ACTH
  • Catecholamines
  • Cortisol
  • GH
  • Hypothalamo-pituitary axis
  • Overload trianing
  • Staleness
  • Testosterone

Fingerprint

Dive into the research topics of 'Impaired pituitary hormonal response to exhaustive exercise in overtrained endurance athletes'. Together they form a unique fingerprint.

Cite this