Impact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma: The quality of liquid-based preparation of cytological slides

Vânia S. Mariano; Paula R.A. Pastrez; Allini Mafra Costa; Denise P. Guimarães; Thiago R. Cunha; Said A.Z. Neto; Christóvam Scapulatempo-Neto; Kari J. Syrjänen; Adhemar Longatto-Filho

doi:10.1159/000496567

Impact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma: The quality of liquid-based preparation of cytological slides

Vânia S. Mariano, Paula R.A. Pastrez, Allini Mafra Costa, Denise P. Guimarães, Thiago R. Cunha, Said A.Z. Neto, Christóvam Scapulatempo-Neto, Kari J. Syrjänen, Adhemar Longatto-Filho^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

Objectives: The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. Methods: Cytological and biopsy specimens were prospectively taken during esophagogastroduode-noscopy of 123 individuals in 2013 and 2014. Cytology samples were maintained in preservative fluid until processing and biopsies were formalin-fixed and paraffin-embedded. Results: Based on endoscopic biopsy results, 70 cases were positive for ESCC whilst 53 were negative for cancer. In addition, brush cytology showed high sensitivity and specificity (98.57 and 96.23%, respectively) in detecting the disease, and high accuracy (97.5%) comparable to that provided by histopathology which is the accepted gold standard. Conclusion: Brush cytology specimens preserved in liquid medium may be a good alternative for ESCC diagnosis.

Original language	English
Pages (from-to)	240-246
Number of pages	7
Journal	Acta Cytologica
Volume	63
Issue number	3
DOIs	https://doi.org/10.1159/000496567
Publication status	Published - 2019
Externally published	Yes

Keywords

Brush cytology
Esophageal squamous cell cancer
Liquid-based cytology
SurePath

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Mariano, V. S., Pastrez, P. R. A., Costa, A. M., Guimarães, D. P., Cunha, T. R., Neto, S. A. Z., Scapulatempo-Neto, C., Syrjänen, K. J., & Longatto-Filho, A. (2019). Impact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma: The quality of liquid-based preparation of cytological slides. Acta Cytologica, 63(3), 240-246. https://doi.org/10.1159/000496567

@article{8b53ac9437ff4fb4b0ce4dc843cdf0bf,

title = "Impact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma: The quality of liquid-based preparation of cytological slides",

abstract = "Objectives: The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. Methods: Cytological and biopsy specimens were prospectively taken during esophagogastroduode-noscopy of 123 individuals in 2013 and 2014. Cytology samples were maintained in preservative fluid until processing and biopsies were formalin-fixed and paraffin-embedded. Results: Based on endoscopic biopsy results, 70 cases were positive for ESCC whilst 53 were negative for cancer. In addition, brush cytology showed high sensitivity and specificity (98.57 and 96.23\%, respectively) in detecting the disease, and high accuracy (97.5\%) comparable to that provided by histopathology which is the accepted gold standard. Conclusion: Brush cytology specimens preserved in liquid medium may be a good alternative for ESCC diagnosis.",

keywords = "Brush cytology, Esophageal squamous cell cancer, Liquid-based cytology, SurePath",

author = "Mariano, \{V{\^a}nia S.\} and Pastrez, \{Paula R.A.\} and Costa, \{Allini Mafra\} and Guimar{\~a}es, \{Denise P.\} and Cunha, \{Thiago R.\} and Neto, \{Said A.Z.\} and Christ{\'o}vam Scapulatempo-Neto and Syrj{\"a}nen, \{Kari J.\} and Adhemar Longatto-Filho",

note = "Publisher Copyright: {\textcopyright} 2019 S. Karger AG, Basel",

year = "2019",

doi = "10.1159/000496567",

language = "English",

volume = "63",

pages = "240--246",

journal = "Acta Cytologica",

issn = "0001-5547",

publisher = "S. Karger AG",

number = "3",

}

Mariano, VS, Pastrez, PRA, Costa, AM, Guimarães, DP, Cunha, TR, Neto, SAZ, Scapulatempo-Neto, C, Syrjänen, KJ & Longatto-Filho, A 2019, 'Impact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma: The quality of liquid-based preparation of cytological slides', Acta Cytologica, vol. 63, no. 3, pp. 240-246. https://doi.org/10.1159/000496567

TY - JOUR

T1 - Impact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma

T2 - The quality of liquid-based preparation of cytological slides

AU - Mariano, Vânia S.

AU - Pastrez, Paula R.A.

AU - Costa, Allini Mafra

AU - Guimarães, Denise P.

AU - Cunha, Thiago R.

AU - Neto, Said A.Z.

AU - Scapulatempo-Neto, Christóvam

AU - Syrjänen, Kari J.

AU - Longatto-Filho, Adhemar

PY - 2019

Y1 - 2019

N2 - Objectives: The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. Methods: Cytological and biopsy specimens were prospectively taken during esophagogastroduode-noscopy of 123 individuals in 2013 and 2014. Cytology samples were maintained in preservative fluid until processing and biopsies were formalin-fixed and paraffin-embedded. Results: Based on endoscopic biopsy results, 70 cases were positive for ESCC whilst 53 were negative for cancer. In addition, brush cytology showed high sensitivity and specificity (98.57 and 96.23%, respectively) in detecting the disease, and high accuracy (97.5%) comparable to that provided by histopathology which is the accepted gold standard. Conclusion: Brush cytology specimens preserved in liquid medium may be a good alternative for ESCC diagnosis.

AB - Objectives: The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. Methods: Cytological and biopsy specimens were prospectively taken during esophagogastroduode-noscopy of 123 individuals in 2013 and 2014. Cytology samples were maintained in preservative fluid until processing and biopsies were formalin-fixed and paraffin-embedded. Results: Based on endoscopic biopsy results, 70 cases were positive for ESCC whilst 53 were negative for cancer. In addition, brush cytology showed high sensitivity and specificity (98.57 and 96.23%, respectively) in detecting the disease, and high accuracy (97.5%) comparable to that provided by histopathology which is the accepted gold standard. Conclusion: Brush cytology specimens preserved in liquid medium may be a good alternative for ESCC diagnosis.

KW - Brush cytology

KW - Esophageal squamous cell cancer

KW - Liquid-based cytology

KW - SurePath

UR - https://www.scopus.com/pages/publications/85063373579

U2 - 10.1159/000496567

DO - 10.1159/000496567

M3 - Article

C2 - 30897562

AN - SCOPUS:85063373579

SN - 0001-5547

VL - 63

SP - 240

EP - 246

JO - Acta Cytologica

JF - Acta Cytologica

IS - 3

ER -

Impact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma: The quality of liquid-based preparation of cytological slides

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