Impact of brush cytology analysis for the diagnosis of esophageal squamous cell carcinoma: The quality of liquid-based preparation of cytological slides

Vânia S. Mariano, Paula R.A. Pastrez, Allini Mafra Costa, Denise P. Guimarães, Thiago R. Cunha, Said A.Z. Neto, Christóvam Scapulatempo-Neto, Kari J. Syrjänen, Adhemar Longatto-Filho*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Objectives: The diagnostic performance of cytology in esophageal squamous cell carcinoma (ESCC) is meticulously described. Methods: Cytological and biopsy specimens were prospectively taken during esophagogastroduode-noscopy of 123 individuals in 2013 and 2014. Cytology samples were maintained in preservative fluid until processing and biopsies were formalin-fixed and paraffin-embedded. Results: Based on endoscopic biopsy results, 70 cases were positive for ESCC whilst 53 were negative for cancer. In addition, brush cytology showed high sensitivity and specificity (98.57 and 96.23%, respectively) in detecting the disease, and high accuracy (97.5%) comparable to that provided by histopathology which is the accepted gold standard. Conclusion: Brush cytology specimens preserved in liquid medium may be a good alternative for ESCC diagnosis.

Original languageEnglish
Pages (from-to)240-246
Number of pages7
JournalActa Cytologica
Volume63
Issue number3
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • Brush cytology
  • Esophageal squamous cell cancer
  • Liquid-based cytology
  • SurePath

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