Immunologically relevant effects of radiation therapy on the tumor microenvironment

Claudia Galassi, Vanessa Klapp, Silvia C Formenti, Sandra Demaria*, Lorenzo Galluzzi*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review


Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

Original languageEnglish
Article numberEBC20220248.
JournalEssays in Biochemistry
Publication statusE-pub ahead of print - 18 May 2023


Dive into the research topics of 'Immunologically relevant effects of radiation therapy on the tumor microenvironment'. Together they form a unique fingerprint.

Cite this