Immunologically relevant effects of radiation therapy on the tumor microenvironment

Claudia Galassi, Vanessa Klapp, Silvia C. Formenti, Sandra Demaria, Lorenzo Galluzzi*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

Original languageEnglish
Article numberEBC20220248.
Pages (from-to)979-989
Number of pages11
JournalEssays in Biochemistry
Volume67
Issue number6
Early online date18 May 2023
DOIs
Publication statusPublished - 28 Sept 2023

Keywords

  • CGAS
  • ICD
  • mtDNA
  • TGFβ
  • TREG cells
  • type I IFN

Fingerprint

Dive into the research topics of 'Immunologically relevant effects of radiation therapy on the tumor microenvironment'. Together they form a unique fingerprint.

Cite this