Immunologically relevant effects of radiation therapy on the tumor microenvironment

Claudia Galassi; Vanessa Klapp; Silvia C Formenti; Sandra Demaria; Lorenzo Galluzzi

doi:10.1042/EBC20220248

Immunologically relevant effects of radiation therapy on the tumor microenvironment

Claudia Galassi, Vanessa Klapp, Silvia C Formenti, Sandra Demaria^*, Lorenzo Galluzzi^*

^*Corresponding author for this work

Tumor Stroma Interactions

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

Original language	English
Article number	EBC20220248.
Journal	Essays in Biochemistry
DOIs	https://doi.org/10.1042/EBC20220248
Publication status	E-pub ahead of print - 18 May 2023

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title = "Immunologically relevant effects of radiation therapy on the tumor microenvironment",

abstract = "Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.",

author = "Claudia Galassi and Vanessa Klapp and Formenti, {Silvia C} and Sandra Demaria and Lorenzo Galluzzi",

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AU - Klapp, Vanessa

AU - Formenti, Silvia C

AU - Demaria, Sandra

AU - Galluzzi, Lorenzo

PY - 2023/5/18

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N2 - Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

AB - Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

UR - https://pubmed.ncbi.nlm.nih.gov/37199227

U2 - 10.1042/EBC20220248

DO - 10.1042/EBC20220248

M3 - Article

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SN - 0071-1365

JO - Essays in Biochemistry

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ER -

Immunologically relevant effects of radiation therapy on the tumor microenvironment

Abstract

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