Immunogenic measles antigens expressed in plants: Role as an edible vaccine for adults

Claude P. Muller; Fred Fack; Benjamin Damien; Fabienne B. Bouche

doi:10.1016/S0264-410X(02)00606-0

Immunogenic measles antigens expressed in plants: Role as an edible vaccine for adults

Claude P. Muller^*, Fred Fack, Benjamin Damien, Fabienne B. Bouche

^*Corresponding author for this work

Department of Cancer Research

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

Vaccine-induced immunity against measles is less robust than natural immunity. Waning of immunity in vaccines may eventually require a revaccination of adults. Measles antigens expressed in plants have been shown to be antigenic and immunogenic both after invasive and oral vaccination. Strategies for the vaccination of adults, the potential of an oral measles vaccine produced in edible plants and the design of suitable antigens are discussed.

Original language	English
Pages (from-to)	816-819
Number of pages	4
Journal	Vaccine
Volume	21
Issue number	7-8
DOIs	https://doi.org/10.1016/S0264-410X(02)00606-0
Publication status	Published - 30 Jan 2003

Keywords

Measles virus
Oral vaccine
Polyepitope
Transgenic carrots
Vaccines

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10.1016/S0264-410X(02)00606-0

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title = "Immunogenic measles antigens expressed in plants: Role as an edible vaccine for adults",

abstract = "Vaccine-induced immunity against measles is less robust than natural immunity. Waning of immunity in vaccines may eventually require a revaccination of adults. Measles antigens expressed in plants have been shown to be antigenic and immunogenic both after invasive and oral vaccination. Strategies for the vaccination of adults, the potential of an oral measles vaccine produced in edible plants and the design of suitable antigens are discussed.",

keywords = "Measles virus, Oral vaccine, Polyepitope, Transgenic carrots, Vaccines",

author = "Muller, {Claude P.} and Fred Fack and Benjamin Damien and Bouche, {Fabienne B.}",

note = "Funding Information: This research was supported by the CRP-Sant{\'e}, Luxembourg, the European Union 4th Framework Programme (Project PL970242) and by a bourse BFR from the Minist{\`e}re de la Recherche to B.D.",

year = "2003",

month = jan,

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doi = "10.1016/S0264-410X(02)00606-0",

language = "English",

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journal = "Vaccine",

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TY - JOUR

T1 - Immunogenic measles antigens expressed in plants

T2 - Role as an edible vaccine for adults

AU - Muller, Claude P.

AU - Fack, Fred

AU - Damien, Benjamin

AU - Bouche, Fabienne B.

N1 - Funding Information: This research was supported by the CRP-Santé, Luxembourg, the European Union 4th Framework Programme (Project PL970242) and by a bourse BFR from the Ministère de la Recherche to B.D.

PY - 2003/1/30

Y1 - 2003/1/30

N2 - Vaccine-induced immunity against measles is less robust than natural immunity. Waning of immunity in vaccines may eventually require a revaccination of adults. Measles antigens expressed in plants have been shown to be antigenic and immunogenic both after invasive and oral vaccination. Strategies for the vaccination of adults, the potential of an oral measles vaccine produced in edible plants and the design of suitable antigens are discussed.

AB - Vaccine-induced immunity against measles is less robust than natural immunity. Waning of immunity in vaccines may eventually require a revaccination of adults. Measles antigens expressed in plants have been shown to be antigenic and immunogenic both after invasive and oral vaccination. Strategies for the vaccination of adults, the potential of an oral measles vaccine produced in edible plants and the design of suitable antigens are discussed.

KW - Measles virus

KW - Oral vaccine

KW - Polyepitope

KW - Transgenic carrots

KW - Vaccines

UR - http://www.scopus.com/inward/record.url?scp=0037472479&partnerID=8YFLogxK

U2 - 10.1016/S0264-410X(02)00606-0

DO - 10.1016/S0264-410X(02)00606-0

M3 - Article

C2 - 12531367

AN - SCOPUS:0037472479

SN - 0264-410X

VL - 21

SP - 816

EP - 819

JO - Vaccine

JF - Vaccine

IS - 7-8

ER -

Immunogenic measles antigens expressed in plants: Role as an edible vaccine for adults

Abstract

Keywords

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