Immune surveillance of the normal human CNS takes place in dependence of the locoregional blood-brain barrier configuration and is mainly performed by CD3+/CD8+ lymphocytes

Christian Loeffler, Klaus Dietz, Ariane Schleich, Holger Schlaszus, Manuel Stoll, Richard Meyermann, Michel Mittelbronn*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Abstract

Despite the blood-brain barrier (BBB) the human CNS is continuously screened by blood-derived immunological cells. In certain brain areas the local BBB configuration grants passage of large molecules, whereas others are better shielded. We investigated whether these regional BBB compositions are paralleled by differences in the degree of cellular immunosurveillance by investigating tissue from 23 normal human brains for several CD markers, FoxP3, granzyme B, and perforin. Our results provide evidence that immunosurveillance is associated with locoregional BBB configuration and is mainly performed by CD3+/CD8+/granzyme B-/perforin- lymphocytes.

Original languageEnglish
Pages (from-to)230-238
Number of pages9
JournalNeuropathology
Volume31
Issue number3
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Keywords

  • Blood-brain barrier
  • CD3
  • CD8
  • CNS
  • Immune surveillance

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