Immune responses to inhalant mammalian allergens

François Hentges, Cathy Léonard, Karthik Arumugam, Christiane Hilger*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    33 Citations (Scopus)


    In Europe and the USA, at least one person in four is exposed every day to inhalant allergens of mammalian origin, a considerable number is regularly exposed for professional reasons and almost everyone is occasionally exposed to inhalant allergens from pets or domestic animals. The production of IgE to these inhalant allergens, often complicated by asthma and rhinitis, defines the atopic status. However, the immune response to these allergens largely imprints the cellular immune compartment and also drives non-IgE humoral immune responses in the allergic and non-allergic population. During the recent years, it has become clear that IgE antibodies recognize mammalian allergens that belong to three protein or glycoprotein families: the secretoglobins, the lipocalins, and the serum albumins. In this article, we review the humoral and cellular immune responses to the major members of these families and try to define common characteristics and also distinctive features.

    Original languageEnglish
    Article number234
    JournalFrontiers in Immunology
    Issue numberMAY
    Publication statusPublished - 2014


    • Albumin
    • Allergen
    • Cellular response
    • Cross-reactivity
    • IgE response
    • Lipocalin
    • Secretoglobin


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