If-2α/ITPR1 axis: A new saboteur of NK-mediated lysis

Yosra Messai, Muhammad Zaeem Noman, Meriem Hasmim, Bernard Escudier, Salem Chouaib*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

We recently investigated the role of von Hippel-Lindau (VHL) mutation and the subsequent induction of hypoxia-inducible factor 2α (HIF-2α) in the regulation of renal cell carcinoma (RCC) susceptibility to natural killer (NK) cell- mediated killing. We demonstrated that the resistance of VHL-mutated RCC cell line 786-0 to NK-mediated lysis requires HIF-2 α and ITPR1, a direct novel target of HIF-2α, through the activation of autophagy in target cells by NK-derived signals.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalOncoImmunology
Volume4
Issue number2
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Autophagy
  • Clear cell renal cell carcinoma
  • HIF-2α
  • ITPR1
  • NK cell
  • PVHL

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