Identification of human parvovirus B19 among measles and rubella suspected patients from Cuba

María de los Ángeles Ribas; Yahisel Tejero; Yanislet Cordero; Daileny Pérez; Aurélie Sausy; Claude P. Muller; Judith M. Hübschen

doi:10.1002/jmv.25444

Identification of human parvovirus B19 among measles and rubella suspected patients from Cuba

María de los Ángeles Ribas^*, Yahisel Tejero, Yanislet Cordero, Daileny Pérez, Aurélie Sausy, Claude P. Muller, Judith M. Hübschen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Abstract

Between September 2014 and December 2015, 298 sera from rash and fever patients from all over Cuba were investigated for specific IgM antibodies against measles, rubella, dengue, human parvovirus B19 (B19V) and human herpesvirus 6 (HHV6) using a commercial enzyme-linked immunosorbent assay kits. B19V IgM positive and equivocal samples were investigated by a polymerase chain reaction and genotyping. No measles, rubella or dengue cases were detected. HHV6-IgM antibodies were confirmed in 5.7% and B19V-IgM antibodies in 10.7% of the patients. A total of 31.3% of the B19V cases were between 5 and 9 years old and 34.4% were 20 years and older. The only B19V sequence obtained belonged to genotype 1a. Diagnosis was established for only 16% of the rash and fever patients, suggesting that other diseases such as Zika or Chikungunya may play a role.

Original language	English
Pages (from-to)	1351-1354
Number of pages	4
Journal	Journal of Medical Virology
Volume	91
Issue number	7
DOIs	https://doi.org/10.1002/jmv.25444
Publication status	Published - Jul 2019

Keywords

Cuba
human parvovirus B19
rash-fever

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title = "Identification of human parvovirus B19 among measles and rubella suspected patients from Cuba",

abstract = "Between September 2014 and December 2015, 298 sera from rash and fever patients from all over Cuba were investigated for specific IgM antibodies against measles, rubella, dengue, human parvovirus B19 (B19V) and human herpesvirus 6 (HHV6) using a commercial enzyme-linked immunosorbent assay kits. B19V IgM positive and equivocal samples were investigated by a polymerase chain reaction and genotyping. No measles, rubella or dengue cases were detected. HHV6-IgM antibodies were confirmed in 5.7% and B19V-IgM antibodies in 10.7% of the patients. A total of 31.3% of the B19V cases were between 5 and 9 years old and 34.4% were 20 years and older. The only B19V sequence obtained belonged to genotype 1a. Diagnosis was established for only 16% of the rash and fever patients, suggesting that other diseases such as Zika or Chikungunya may play a role.",

keywords = "Cuba, human parvovirus B19, rash-fever",

author = "{de los {\'A}ngeles Ribas}, Mar{\'i}a and Yahisel Tejero and Yanislet Cordero and Daileny P{\'e}rez and Aur{\'e}lie Sausy and Muller, {Claude P.} and H{\"u}bschen, {Judith M.}",

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year = "2019",

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doi = "10.1002/jmv.25444",

language = "English",

volume = "91",

pages = "1351--1354",

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T1 - Identification of human parvovirus B19 among measles and rubella suspected patients from Cuba

AU - de los Ángeles Ribas, María

AU - Tejero, Yahisel

AU - Cordero, Yanislet

AU - Pérez, Daileny

AU - Sausy, Aurélie

AU - Muller, Claude P.

AU - Hübschen, Judith M.

PY - 2019/7

Y1 - 2019/7

N2 - Between September 2014 and December 2015, 298 sera from rash and fever patients from all over Cuba were investigated for specific IgM antibodies against measles, rubella, dengue, human parvovirus B19 (B19V) and human herpesvirus 6 (HHV6) using a commercial enzyme-linked immunosorbent assay kits. B19V IgM positive and equivocal samples were investigated by a polymerase chain reaction and genotyping. No measles, rubella or dengue cases were detected. HHV6-IgM antibodies were confirmed in 5.7% and B19V-IgM antibodies in 10.7% of the patients. A total of 31.3% of the B19V cases were between 5 and 9 years old and 34.4% were 20 years and older. The only B19V sequence obtained belonged to genotype 1a. Diagnosis was established for only 16% of the rash and fever patients, suggesting that other diseases such as Zika or Chikungunya may play a role.

AB - Between September 2014 and December 2015, 298 sera from rash and fever patients from all over Cuba were investigated for specific IgM antibodies against measles, rubella, dengue, human parvovirus B19 (B19V) and human herpesvirus 6 (HHV6) using a commercial enzyme-linked immunosorbent assay kits. B19V IgM positive and equivocal samples were investigated by a polymerase chain reaction and genotyping. No measles, rubella or dengue cases were detected. HHV6-IgM antibodies were confirmed in 5.7% and B19V-IgM antibodies in 10.7% of the patients. A total of 31.3% of the B19V cases were between 5 and 9 years old and 34.4% were 20 years and older. The only B19V sequence obtained belonged to genotype 1a. Diagnosis was established for only 16% of the rash and fever patients, suggesting that other diseases such as Zika or Chikungunya may play a role.

KW - Cuba

KW - human parvovirus B19

KW - rash-fever

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DO - 10.1002/jmv.25444

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SN - 0146-6615

VL - 91

SP - 1351

EP - 1354

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 7

ER -

Identification of human parvovirus B19 among measles and rubella suspected patients from Cuba

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