TY - JOUR
T1 - Identification of evidence-based biospecimen quality-control tools
T2 - A report of the international society for biological and environmental repositories (ISBER) biospecimen science working group
AU - Betsou, Fotini
AU - Gunter, Elaine
AU - Clements, Judith
AU - De Souza, Yvonne
AU - Goddard, Katrina A.B.
AU - Guadagni, Fiorella
AU - Yan, Wusheng
AU - Skubitz, Amy
AU - Somiari, Stella
AU - Yeadon, Trina
AU - Chuaqui, Rodrigo
PY - 2013
Y1 - 2013
N2 - Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is lacking, however, regarding optimal sample quality-control (QC) tools (ie, markers and assays). The aim of this review was to identify QC tools, both for fluid and solid-tissue samples, based on a comprehensive and critical literature review. The most readily applicable tools are those with a known threshold for the preanalytical variation and a known reference range for the QC analyte. Only a few meaningful markers were identified that meet these criteria, such as CD40L for assessing serum exposure at high temperatures and VEGF for assessing serum freeze-thawing. To fully assess biospecimen quality, multiple QC markers are needed. Here we present the most promising biospecimen QC tools that were identified.
AB - Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is lacking, however, regarding optimal sample quality-control (QC) tools (ie, markers and assays). The aim of this review was to identify QC tools, both for fluid and solid-tissue samples, based on a comprehensive and critical literature review. The most readily applicable tools are those with a known threshold for the preanalytical variation and a known reference range for the QC analyte. Only a few meaningful markers were identified that meet these criteria, such as CD40L for assessing serum exposure at high temperatures and VEGF for assessing serum freeze-thawing. To fully assess biospecimen quality, multiple QC markers are needed. Here we present the most promising biospecimen QC tools that were identified.
UR - https://www.scopus.com/pages/publications/84875425056
U2 - 10.1016/j.jmoldx.2012.06.008
DO - 10.1016/j.jmoldx.2012.06.008
M3 - Article
AN - SCOPUS:84875425056
SN - 1525-1578
VL - 15
SP - 3
EP - 16
JO - Journal of Molecular Diagnostics
JF - Journal of Molecular Diagnostics
IS - 1
ER -