Identification of 677 C > T Polymorphism of LRP1 gene by PCR-RFLP method

Amela Jusic; Aldijana Avdic; Vesna Hadžiavdic; Inela Junuzović; Dženita Kurtčehajic

doi:10.18421/TEM74-17

Identification of 677 C > T Polymorphism of LRP1 gene by PCR-RFLP method

Amela Jusic^*, Aldijana Avdic, Vesna Hadžiavdic, Inela Junuzović, Dženita Kurtčehajic

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The 677 C > T (rs1799986) polymorphism is located at position 677 in exon 3 of the LRP1 gene. The aim of this study was to determine the allele and genotype frequencies of the polymorphism in Bosnian population. The study included 100 unrelated healthy individuals. Genotyping of 677 C > T polymorphism of the LRP1 gene was performed with PCR-RFLP method. The most frequent allele was the C allele (91%), while the T allele was represented by 9%. These results suggested that presence of the 677 C > T polymorphism of the LRP1 gene in our population should be a base for further case-control association or population genetics studies.

Original language	English
Pages (from-to)	803-807
Number of pages	5
Journal	TEM Journal
Volume	7
Issue number	4
DOIs	https://doi.org/10.18421/TEM74-17
Publication status	Published - 2018
Externally published	Yes

Keywords

LRP1 gene
PCR-RFLP method

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10.18421/TEM74-17

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title = "Identification of 677 C > T Polymorphism of LRP1 gene by PCR-RFLP method",

abstract = "The 677 C > T (rs1799986) polymorphism is located at position 677 in exon 3 of the LRP1 gene. The aim of this study was to determine the allele and genotype frequencies of the polymorphism in Bosnian population. The study included 100 unrelated healthy individuals. Genotyping of 677 C > T polymorphism of the LRP1 gene was performed with PCR-RFLP method. The most frequent allele was the C allele (91%), while the T allele was represented by 9%. These results suggested that presence of the 677 C > T polymorphism of the LRP1 gene in our population should be a base for further case-control association or population genetics studies.",

keywords = "LRP1 gene, PCR-RFLP method",

author = "Amela Jusic and Aldijana Avdic and Vesna Had{\v z}iavdic and Inela Junuzovi{\'c} and D{\v z}enita Kurt{\v c}ehajic",

note = "Publisher Copyright: {\textcopyright} 2018 Amela Jusic et al; published by UIKTEN.",

year = "2018",

doi = "10.18421/TEM74-17",

language = "English",

volume = "7",

pages = "803--807",

journal = "TEM Journal",

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TY - JOUR

T1 - Identification of 677 C > T Polymorphism of LRP1 gene by PCR-RFLP method

AU - Jusic, Amela

AU - Avdic, Aldijana

AU - Hadžiavdic, Vesna

AU - Junuzović, Inela

AU - Kurtčehajic, Dženita

PY - 2018

Y1 - 2018

N2 - The 677 C > T (rs1799986) polymorphism is located at position 677 in exon 3 of the LRP1 gene. The aim of this study was to determine the allele and genotype frequencies of the polymorphism in Bosnian population. The study included 100 unrelated healthy individuals. Genotyping of 677 C > T polymorphism of the LRP1 gene was performed with PCR-RFLP method. The most frequent allele was the C allele (91%), while the T allele was represented by 9%. These results suggested that presence of the 677 C > T polymorphism of the LRP1 gene in our population should be a base for further case-control association or population genetics studies.

AB - The 677 C > T (rs1799986) polymorphism is located at position 677 in exon 3 of the LRP1 gene. The aim of this study was to determine the allele and genotype frequencies of the polymorphism in Bosnian population. The study included 100 unrelated healthy individuals. Genotyping of 677 C > T polymorphism of the LRP1 gene was performed with PCR-RFLP method. The most frequent allele was the C allele (91%), while the T allele was represented by 9%. These results suggested that presence of the 677 C > T polymorphism of the LRP1 gene in our population should be a base for further case-control association or population genetics studies.

KW - LRP1 gene

KW - PCR-RFLP method

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DO - 10.18421/TEM74-17

M3 - Article

AN - SCOPUS:85058118766

SN - 2217-8309

VL - 7

SP - 803

EP - 807

JO - TEM Journal

JF - TEM Journal

IS - 4

ER -

Identification of 677 C > T Polymorphism of LRP1 gene by PCR-RFLP method

Abstract

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