Hypoxia promotes tumor growth in linking angiogenesis to immune escape

Salem Chouaib*, Yosra Messai, Sophie Couve, Bernard Escudier, Meriem Hasmim, Muhammad Zaeem Noman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

147 Citations (Scopus)

Abstract

Despite the impressive progress over the past decade, in the field of tumor immunology, such as the identification of tumor antigens and antigenic peptides, there are still many obstacles in eliciting an effective immune response to eradicate cancer. It has become increasingly clear that tumor microenvironment plays a crucial role in the control of immune protection. Tumors have evolved to utilize hypoxic stress to their own advantage by activating key biochemical and cellular pathways that are important in progression, survival, and metastasis. Hypoxia-inducible factor (HIF-1) and vascular endothelial growth factor (VEGF) play a determinant role in promoting tumor cell growth and survival. Hypoxia contributes to immune suppression by activating HIF-1 and VEGF pathways. Accumulating evidence suggests a link between hypoxia and tumor tolerance to immune surveillance through the recruitment of regulatory cells (regulatory T cells and myeloid derived suppressor cells). In this regard, hypoxia (HIF-1α and VEGF) is emerging as an attractive target for cancer therapy. How the microenvironmental hypoxia poses both obstacles and opportunities for new therapeutic immune interventions will be discussed.

Original languageEnglish
Article numberArticle 21
JournalFrontiers in Immunology
Volume3
Issue numberFEB
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Angiogenesis
  • Hifα
  • Hypoxia
  • Immune tolerance
  • Tumor progression

Fingerprint

Dive into the research topics of 'Hypoxia promotes tumor growth in linking angiogenesis to immune escape'. Together they form a unique fingerprint.

Cite this