TY - JOUR
T1 - Hypoxia
T2 - A key player in antitumor immune response. A review in the theme: Cellular responses to hypoxia
AU - Noman, Muhammad Zaeem
AU - Hasmim, Meriem
AU - Messai, Yosra
AU - Terry, Stéphane
AU - Kieda, Claudine
AU - Janji, Bassam
AU - Chouaib, Salem
N1 - Publisher Copyright:
© 2015 the American Physiological Society.
PY - 2015
Y1 - 2015
N2 - The tumor microenvironment is a complex system, playing an important role in tumor development and progression. Besides cellular stromal components, extracellular matrix fibers, cytokines, and other metabolic mediators are also involved. In this review we outline the potential role of hypoxia, a major feature of most solid tumors, within the tumor microenvironment and how it contributes to immune resistance and immune suppression/tolerance and can be detrimental to antitumor effector cell functions. We also outline how hypoxic stress influences immunosuppressive pathways involving macrophages, myeloid-derived suppressor cells, T regulatory cells, and immune checkpoints and how it may confer tumor resistance. Finally, we discuss how microenvironmental hypoxia poses both obstacles and opportunities for new therapeutic immune interventions.
AB - The tumor microenvironment is a complex system, playing an important role in tumor development and progression. Besides cellular stromal components, extracellular matrix fibers, cytokines, and other metabolic mediators are also involved. In this review we outline the potential role of hypoxia, a major feature of most solid tumors, within the tumor microenvironment and how it contributes to immune resistance and immune suppression/tolerance and can be detrimental to antitumor effector cell functions. We also outline how hypoxic stress influences immunosuppressive pathways involving macrophages, myeloid-derived suppressor cells, T regulatory cells, and immune checkpoints and how it may confer tumor resistance. Finally, we discuss how microenvironmental hypoxia poses both obstacles and opportunities for new therapeutic immune interventions.
KW - Antitumor immune response
KW - Autophagy
KW - Cancer stem cells
KW - Circulating tumor cells
KW - Epithelial-mesenchymal transition
KW - Hypoxia
KW - Hypoxia-inducible factor
KW - Immune suppression
KW - Lymphoid cells
KW - Myeloid cells
KW - Programmed death-ligand 1
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=84946074699&partnerID=8YFLogxK
U2 - 10.1152/ajpcell.00207.2015
DO - 10.1152/ajpcell.00207.2015
M3 - Article
C2 - 26310815
AN - SCOPUS:84946074699
SN - 0363-6143
VL - 309
SP - C569-C579
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
IS - 9
ER -