Hypoxia: A Formidable Saboteur of the Anti-tumor Response

Meriem Hasmim, Yosra Messai, Stéphane Terry, Bassam Janji, Muhammad Zaeem Noman, Salem Chouaib

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    The tumor microenvironment (TME) promotes neoplastic transformation, supports tumor growth and invasion, protects the tumor from host immunity and fosters therapeutic resistance. It is well established that tumor stroma components are engaged in an active and complex molecular cross-talk that has serious implications for immunological recognition of tumor cells in shaping the microenvironment. In this regard, a common feature of solid tumors and one of the hallmarks of the TME is at present attracting a particular and increased attention in the field of cancer immunology since hypoxic stress impacts angiogenesis, tumor progression and immune tolerance. In this chapter, we will discuss how tumors use hypoxic stress to their own advantage by activating key biochemical and cellular pathways that are important in their progression and survival and how hypoxic stress induces tumor target adaptation that compromises the effectiveness of CTL activity. In this respect, modulating hypoxia may be a good strategy to control tumor progression at different fronts.
    Original languageEnglish
    Title of host publicationResistance of Cancer Cells to CTL-Mediated Immunotherapy
    EditorsBenjamin Bonavida, Salem Chouaib
    Number of pages28
    VolumeSeries Resistance to Targeted Anti-Cancer Therapeutics, Vol. 7
    ISBN (Print)978-3-319-17806-6
    Publication statusPublished - 20 Jun 2015


    • CTL Hypoxia HIF Hypoxic stress Tumor microenvironment Resistance to cytotoxic effectors


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