Hypocholesterolemia, an unfavorable feature of prognostic value in chronic myeloid leukemia

Claude P. Muller; Ansgar U. Wagner; Christa Maucher; Berthold Steinke

doi:10.1111/j.1600-0609.1989.tb00288.x

Hypocholesterolemia, an unfavorable feature of prognostic value in chronic myeloid leukemia

Claude P. Muller^*, Ansgar U. Wagner, Christa Maucher, Berthold Steinke

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

In chronic myeloid leukemia (CML) low serum cholesterol is not uncommon and has been linked to the activity of the disease. Despite these observations, most studies concerned with prognostic signs in CML have not included cholesterol. In our study, cholesterol correlated positively with survival (p = 0.0012) and with the duration of chronic phase (p = 0.0059) in a univariate analysis. The multivariate Cox regression model selected cholesterol as a parameter of additive prognostic value in addition to marrow myeloblasts plus promyelocytes, sex, eosinophilia and lactate dehydrogenase.

Original language	English
Pages (from-to)	235-239
Number of pages	5
Journal	European Journal of Haematology
Volume	43
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0609.1989.tb00288.x
Publication status	Published - Sept 1989
Externally published	Yes

Keywords

chronic myeloid leukemia
hypocholesterolemia
prognosis

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10.1111/j.1600-0609.1989.tb00288.x

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abstract = "In chronic myeloid leukemia (CML) low serum cholesterol is not uncommon and has been linked to the activity of the disease. Despite these observations, most studies concerned with prognostic signs in CML have not included cholesterol. In our study, cholesterol correlated positively with survival (p = 0.0012) and with the duration of chronic phase (p = 0.0059) in a univariate analysis. The multivariate Cox regression model selected cholesterol as a parameter of additive prognostic value in addition to marrow myeloblasts plus promyelocytes, sex, eosinophilia and lactate dehydrogenase.",

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AU - Muller, Claude P.

AU - Wagner, Ansgar U.

AU - Maucher, Christa

AU - Steinke, Berthold

PY - 1989/9

Y1 - 1989/9

N2 - In chronic myeloid leukemia (CML) low serum cholesterol is not uncommon and has been linked to the activity of the disease. Despite these observations, most studies concerned with prognostic signs in CML have not included cholesterol. In our study, cholesterol correlated positively with survival (p = 0.0012) and with the duration of chronic phase (p = 0.0059) in a univariate analysis. The multivariate Cox regression model selected cholesterol as a parameter of additive prognostic value in addition to marrow myeloblasts plus promyelocytes, sex, eosinophilia and lactate dehydrogenase.

AB - In chronic myeloid leukemia (CML) low serum cholesterol is not uncommon and has been linked to the activity of the disease. Despite these observations, most studies concerned with prognostic signs in CML have not included cholesterol. In our study, cholesterol correlated positively with survival (p = 0.0012) and with the duration of chronic phase (p = 0.0059) in a univariate analysis. The multivariate Cox regression model selected cholesterol as a parameter of additive prognostic value in addition to marrow myeloblasts plus promyelocytes, sex, eosinophilia and lactate dehydrogenase.

KW - chronic myeloid leukemia

KW - hypocholesterolemia

KW - prognosis

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ER -

Hypocholesterolemia, an unfavorable feature of prognostic value in chronic myeloid leukemia

Abstract

Keywords

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