Hypocholesterolemia, an unfavorable feature of prognostic value in chronic myeloid leukemia

Claude P. Muller*, Ansgar U. Wagner, Christa Maucher, Berthold Steinke

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

In chronic myeloid leukemia (CML) low serum cholesterol is not uncommon and has been linked to the activity of the disease. Despite these observations, most studies concerned with prognostic signs in CML have not included cholesterol. In our study, cholesterol correlated positively with survival (p = 0.0012) and with the duration of chronic phase (p = 0.0059) in a univariate analysis. The multivariate Cox regression model selected cholesterol as a parameter of additive prognostic value in addition to marrow myeloblasts plus promyelocytes, sex, eosinophilia and lactate dehydrogenase.

Original languageEnglish
Pages (from-to)235-239
Number of pages5
JournalEuropean Journal of Haematology
Volume43
Issue number3
DOIs
Publication statusPublished - Sep 1989
Externally publishedYes

Keywords

  • chronic myeloid leukemia
  • hypocholesterolemia
  • prognosis

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