HuMiX: A microfluidics-based in vitro co-culture device for investigating host-microbe molecular interactions

Pranjul Shah*, Joelle Fritz, Matt Estes, Frederic Zenhausern, Paul Wilmes

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Lack of in vitro co-culture devices hinder investigations aiming to uncover the role of human-associated microbial community imbalances in causation of numerous medical conditions. We describe the development and validation of a microfluidics-based co-culture device (HuMiX) allowing co-cultivation of human and microbial cells. The modular device architecture provides access to individual co-cultured contingents following targeted perturbations which facilitate high resolution systemic investigations into the hypothesized role of the complex host-microbial molecular interactions in the pathogenesis of idiopathic medical conditions.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages300-302
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 2014
Externally publishedYes
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 26 Oct 201430 Oct 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/TerritoryUnited States
CitySan Antonio
Period26/10/1430/10/14

Keywords

  • Co-culture
  • Gut on chip
  • Host-Microbe interaction
  • Microbiome
  • Organs on chip

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