Human CD56bright NK cells: An update

Tatiana Michel, Aurélie Poli, Angelica Cuapio, Benjamin Briquemont, Gilles Iserentant, Markus Ollert, Jacques Zimmer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

267 Citations (Scopus)


Human NK cells can be subdivided into various subsets based on the relative expression of CD16 and CD56. In particular, CD56brightCD16-/dim NK cells are the focus of interest. They are considered efficient cytokine producers endowed with immunoregulatory properties, but they can also become cytotoxic upon appropriate activation. These cells were shown to play a role in different disease states, such as cancer, autoimmunity, neuroinflammation, and infection. Although their phenotype and functional properties are well known and have been extensively studied, their lineage relationship with other NK cell subsets is not fully defined, nor is their precise hematopoietic origin. In this article, we summarize recent studies about CD56bright NK cells in health and disease and briefly discuss the current controversies surrounding them.

Original languageEnglish
Pages (from-to)2923-2931
Number of pages9
JournalJournal of Immunology
Issue number7
Publication statusPublished - 1 Apr 2016


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