TY - JOUR
T1 - Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy
AU - Winston, A.
AU - Stöhr, W.
AU - Antinori, A.
AU - Arenas-Pinto, A.
AU - Llibre, J. M.
AU - Amieva, H.
AU - Cabié, A.
AU - Williams, I.
AU - Di Perri, G.
AU - Tellez, M. J.
AU - Rockstroh, J.
AU - Babiker, A.
AU - Pozniak, A.
AU - Raffi, F.
AU - Richert, L.
AU - Dedes, Nikos
AU - Chene, Genevieve
AU - Allavena, Clotilde
AU - Autran, Brigitte
AU - Bucciardini, Raffaella
AU - Vella, Stefano
AU - Horban, Andrzej
AU - Arribas, José Ramón
AU - Boffito, Marta
AU - Pillay, Deenan
AU - Franquet, Xavier
AU - Schwarze, Siegfried
AU - Grarup, Jesper
AU - Fischer, Aurelie
AU - Wallet, Cedrick
AU - Diallo, Alpha
AU - Molina, Jean Michel
AU - Saillard, Juliette
AU - Moecklinghoff, Christiane
AU - Stellbrink, Hans Jurgen
AU - Leeuwen, Remko
AU - Gatell, Jose
AU - Sandstrom, Eric
AU - Flepp, Markus
AU - Ewings, Fiona
AU - George, Elizabeth C.
AU - Hudson, Fleur
AU - Pearce, Gillian
AU - Quercia, Romina
AU - Rogatto, Felipe
AU - Leavitt, Randi
AU - Nguyen, Bach Yen
AU - Goebel, Frank
AU - Marcotullio, Simone
AU - Kaur, Navrup
AU - the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 Study Group
N1 - Publisher Copyright:
© 2015 British HIV Association
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Objectives: Deficits in cognitive function remain prevalent in HIV-infected individuals. The aim of this European multicentre study was to assess factors associated with cognitive function in antiretroviral therapy (ART)-naïve HIV-infected subjects at the time of enrolment in the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 study. Methods: Prior to starting ART, seven cognitive tests exploring domains including episodic memory, verbal fluency, executive function and psychomotor speed were administered with scores standardized to z-score using the study population sample mean and standard deviation. The primary measure was overall z-score average (NPZ). We assessed associations between baseline factors and test results using multivariable regression models. Results: Of 283 subjects with baseline cognitive assessments, 90% were male and 12% of black ethnicity. Median (interquartile range) age, years of education, years of known HIV infection, baseline CD4 count and baseline HIV RNA were 39 (31, 47) years, 13 (11, 17) years, 1 (0, 4) years, 344 (279, 410) cells/μL and 4.74 (4.28, 5.14) log10 HIV-1 RNA copies/mL, respectively. Forty per cent were current smokers. Factors significantly associated with poorer overall cognitive performance in multivariable models included older age, shorter duration of education, black ethnicity, lower height, and lower plasma HIV RNA. Conclusions: In this large, European-wide, ART-naïve population with relatively preserved immunity and early HIV infection, cognitive function scores at the time of ART initiation were associated with demographic and HIV-disease factors.
AB - Objectives: Deficits in cognitive function remain prevalent in HIV-infected individuals. The aim of this European multicentre study was to assess factors associated with cognitive function in antiretroviral therapy (ART)-naïve HIV-infected subjects at the time of enrolment in the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 study. Methods: Prior to starting ART, seven cognitive tests exploring domains including episodic memory, verbal fluency, executive function and psychomotor speed were administered with scores standardized to z-score using the study population sample mean and standard deviation. The primary measure was overall z-score average (NPZ). We assessed associations between baseline factors and test results using multivariable regression models. Results: Of 283 subjects with baseline cognitive assessments, 90% were male and 12% of black ethnicity. Median (interquartile range) age, years of education, years of known HIV infection, baseline CD4 count and baseline HIV RNA were 39 (31, 47) years, 13 (11, 17) years, 1 (0, 4) years, 344 (279, 410) cells/μL and 4.74 (4.28, 5.14) log10 HIV-1 RNA copies/mL, respectively. Forty per cent were current smokers. Factors significantly associated with poorer overall cognitive performance in multivariable models included older age, shorter duration of education, black ethnicity, lower height, and lower plasma HIV RNA. Conclusions: In this large, European-wide, ART-naïve population with relatively preserved immunity and early HIV infection, cognitive function scores at the time of ART initiation were associated with demographic and HIV-disease factors.
KW - HIV
KW - antiretroviral naïve
KW - cognitive
KW - neuropsychological tests
UR - http://www.scopus.com/inward/record.url?scp=84975246442&partnerID=8YFLogxK
U2 - 10.1111/hiv.12344
DO - 10.1111/hiv.12344
M3 - Article
C2 - 26611175
AN - SCOPUS:84975246442
SN - 1464-2662
VL - 17
SP - 471
EP - 478
JO - HIV Medicine
JF - HIV Medicine
IS - 6
ER -