TY - JOUR
T1 - Holocord pilocytic astrocytoma-Case report and review of the literature
AU - Schittenhelm, Jens
AU - Ebner, Florian H.
AU - Tatagiba, Marcos
AU - Wolff, Markus
AU - Nägele, Thomas
AU - Meyermann, Richard
AU - Mittelbronn, Michel
PY - 2009/2
Y1 - 2009/2
N2 - Intramedullary glial neoplasms affecting the entire cord from the cervicomedullary junction to the conus are termed "holocord tumors" and those diagnosed as pilocytic astrocytoma are rare. Herein, we present a 13-year-old girl with a tumor extending from the cervicomedullary junction to the conus which was partially resected in a four-stage approach. Histopathological examination of all specimens resulted in diagnosis of a pilocytic astrocytoma. Although no signs of atypia were present, an elevated proliferative activity of endothelial vessels was noted. Residual parts of the tumor showed progress making additional surgery necessary. Therapy and its consequences are discussed and an overview of the literature of these rare longitudinally extensive intramedullary lesions is given.
AB - Intramedullary glial neoplasms affecting the entire cord from the cervicomedullary junction to the conus are termed "holocord tumors" and those diagnosed as pilocytic astrocytoma are rare. Herein, we present a 13-year-old girl with a tumor extending from the cervicomedullary junction to the conus which was partially resected in a four-stage approach. Histopathological examination of all specimens resulted in diagnosis of a pilocytic astrocytoma. Although no signs of atypia were present, an elevated proliferative activity of endothelial vessels was noted. Residual parts of the tumor showed progress making additional surgery necessary. Therapy and its consequences are discussed and an overview of the literature of these rare longitudinally extensive intramedullary lesions is given.
KW - Intramedullary astrocytoma
KW - Pilocytic astrocytoma
KW - Spinal cord tumor
UR - http://www.scopus.com/inward/record.url?scp=58349089149&partnerID=8YFLogxK
U2 - 10.1016/j.clineuro.2008.09.014
DO - 10.1016/j.clineuro.2008.09.014
M3 - Article
C2 - 18980798
AN - SCOPUS:58349089149
SN - 0303-8467
VL - 111
SP - 203
EP - 207
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
IS - 2
ER -