HLA in isolated REM sleep behavior disorder and Lewy body dementia

Eric Yu; Lynne Krohn; Jennifer A Ruskey; Farnaz Asayesh; Dan Spiegelman; Zalak Shah; Ruth Chia; Isabelle Arnulf; Michele T M Hu; Jacques Y Montplaisir; Jean-François Gagnon; Alex Desautels; Yves Dauvilliers; Gian Luigi Gigli; Mariarosaria Valente; Francesco Janes; Andrea Bernardini; Birgit Högl; Ambra Stefani; Abubaker Ibrahim; Anna Heidbreder; Karel Sonka; Petr Dusek; David Kemlink; Wolfgang Oertel; Annette Janzen; Giuseppe Plazzi; Elena Antelmi; Michela Figorilli; Monica Puligheddu; Brit Mollenhauer; Claudia Trenkwalder; Friederike Sixel-Döring; Valérie Cochen De Cock; Luigi Ferini-Strambi; Femke Dijkstra; Mineke Viaene; Beatriz Abril; Bradley F Boeve; Guy A Rouleau; Ronald B Postuma; Sonja W Scholz; Ziv Gan-Or; International LBD Genomics Consortium; Rejko Krüger

doi:10.1002/acn3.51841

HLA in isolated REM sleep behavior disorder and Lewy body dementia

Eric Yu
, Lynne Krohn
, Jennifer A Ruskey
, Farnaz Asayesh
, Dan Spiegelman
, Zalak Shah
, Ruth Chia
, Isabelle Arnulf
, Michele T M Hu
, Jacques Y Montplaisir
, Jean-François Gagnon
, Alex Desautels
, Yves Dauvilliers
, Gian Luigi Gigli
, Mariarosaria Valente
, Francesco Janes
, Andrea Bernardini
, Birgit Högl
, Ambra Stefani
, Abubaker Ibrahim

Anna Heidbreder, Karel Sonka, Petr Dusek, David Kemlink, Wolfgang Oertel, Annette Janzen, Giuseppe Plazzi, Elena Antelmi, Michela Figorilli, Monica Puligheddu, Brit Mollenhauer, Claudia Trenkwalder, Friederike Sixel-Döring, Valérie Cochen De Cock, Luigi Ferini-Strambi, Femke Dijkstra, Mineke Viaene, Beatriz Abril, Bradley F Boeve, Guy A Rouleau, Ronald B Postuma, Sonja W Scholz, Ziv Gan-Or^*, International LBD Genomics Consortium, Rejko Krüger

^*Corresponding author for this work

Transversal Translational Medicine

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.

Original language	English
Pages (from-to)	1682-1687
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	10
Issue number	9
DOIs	https://doi.org/10.1002/acn3.51841
Publication status	Published - Sept 2023

Keywords

Humans
Lewy Body Disease/genetics
REM Sleep Behavior Disorder/genetics
Synucleinopathies/genetics
HLA-DRB1 Chains/genetics
HLA Antigens

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10.1002/acn3.51841Licence: CC BY

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Yu, E., Krohn, L., Ruskey, J. A., Asayesh, F., Spiegelman, D., Shah, Z., Chia, R., Arnulf, I., Hu, M. T. M., Montplaisir, J. Y., Gagnon, J.-F., Desautels, A., Dauvilliers, Y., Gigli, G. L., Valente, M., Janes, F., Bernardini, A., Högl, B., Stefani, A., ... Krüger, R. (2023). HLA in isolated REM sleep behavior disorder and Lewy body dementia. Annals of Clinical and Translational Neurology, 10(9), 1682-1687. https://doi.org/10.1002/acn3.51841

@article{9691f56269324275a51396709e7e2691,

title = "HLA in isolated REM sleep behavior disorder and Lewy body dementia",

abstract = "Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95\% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95\%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95\%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95\%CI = 1.08-1.35, p = 1.35e-03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.",

keywords = "Humans, Lewy Body Disease/genetics, REM Sleep Behavior Disorder/genetics, Synucleinopathies/genetics, HLA-DRB1 Chains/genetics, HLA Antigens",

author = "Eric Yu and Lynne Krohn and Ruskey, \{Jennifer A\} and Farnaz Asayesh and Dan Spiegelman and Zalak Shah and Ruth Chia and Isabelle Arnulf and Hu, \{Michele T M\} and Montplaisir, \{Jacques Y\} and Jean-Fran{\c c}ois Gagnon and Alex Desautels and Yves Dauvilliers and Gigli, \{Gian Luigi\} and Mariarosaria Valente and Francesco Janes and Andrea Bernardini and Birgit H{\"o}gl and Ambra Stefani and Abubaker Ibrahim and Anna Heidbreder and Karel Sonka and Petr Dusek and David Kemlink and Wolfgang Oertel and Annette Janzen and Giuseppe Plazzi and Elena Antelmi and Michela Figorilli and Monica Puligheddu and Brit Mollenhauer and Claudia Trenkwalder and Friederike Sixel-D{\"o}ring and \{Cochen De Cock\}, Val{\'e}rie and Luigi Ferini-Strambi and Femke Dijkstra and Mineke Viaene and Beatriz Abril and Boeve, \{Bradley F\} and Rouleau, \{Guy A\} and Postuma, \{Ronald B\} and Scholz, \{Sonja W\} and Ziv Gan-Or and \{International LBD Genomics Consortium\} and Rejko Kr{\"u}ger",

note = "{\textcopyright} 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.",

year = "2023",

month = sep,

doi = "10.1002/acn3.51841",

language = "English",

volume = "10",

pages = "1682--1687",

journal = "Annals of Clinical and Translational Neurology",

issn = "2328-9503",

publisher = "John Wiley \& Sons Inc.",

number = "9",

}

Yu, E, Krohn, L, Ruskey, JA, Asayesh, F, Spiegelman, D, Shah, Z, Chia, R, Arnulf, I, Hu, MTM, Montplaisir, JY, Gagnon, J-F, Desautels, A, Dauvilliers, Y, Gigli, GL, Valente, M, Janes, F, Bernardini, A, Högl, B, Stefani, A, Ibrahim, A, Heidbreder, A, Sonka, K, Dusek, P, Kemlink, D, Oertel, W, Janzen, A, Plazzi, G, Antelmi, E, Figorilli, M, Puligheddu, M, Mollenhauer, B, Trenkwalder, C, Sixel-Döring, F, Cochen De Cock, V, Ferini-Strambi, L, Dijkstra, F, Viaene, M, Abril, B, Boeve, BF, Rouleau, GA, Postuma, RB, Scholz, SW, Gan-Or, Z, International LBD Genomics Consortium & Krüger, R 2023, 'HLA in isolated REM sleep behavior disorder and Lewy body dementia', Annals of Clinical and Translational Neurology, vol. 10, no. 9, pp. 1682-1687. https://doi.org/10.1002/acn3.51841

TY - JOUR

T1 - HLA in isolated REM sleep behavior disorder and Lewy body dementia

AU - Yu, Eric

AU - Krohn, Lynne

AU - Ruskey, Jennifer A

AU - Asayesh, Farnaz

AU - Spiegelman, Dan

AU - Shah, Zalak

AU - Chia, Ruth

AU - Arnulf, Isabelle

AU - Hu, Michele T M

AU - Montplaisir, Jacques Y

AU - Gagnon, Jean-François

AU - Desautels, Alex

AU - Dauvilliers, Yves

AU - Gigli, Gian Luigi

AU - Valente, Mariarosaria

AU - Janes, Francesco

AU - Bernardini, Andrea

AU - Högl, Birgit

AU - Stefani, Ambra

AU - Ibrahim, Abubaker

AU - Heidbreder, Anna

AU - Sonka, Karel

AU - Dusek, Petr

AU - Kemlink, David

AU - Oertel, Wolfgang

AU - Janzen, Annette

AU - Plazzi, Giuseppe

AU - Antelmi, Elena

AU - Figorilli, Michela

AU - Puligheddu, Monica

AU - Mollenhauer, Brit

AU - Trenkwalder, Claudia

AU - Sixel-Döring, Friederike

AU - Cochen De Cock, Valérie

AU - Ferini-Strambi, Luigi

AU - Dijkstra, Femke

AU - Viaene, Mineke

AU - Abril, Beatriz

AU - Boeve, Bradley F

AU - Rouleau, Guy A

AU - Postuma, Ronald B

AU - Scholz, Sonja W

AU - Gan-Or, Ziv

AU - International LBD Genomics Consortium

AU - Krüger, Rejko

PY - 2023/9

Y1 - 2023/9

N2 - Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.

AB - Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.

KW - Humans

KW - Lewy Body Disease/genetics

KW - REM Sleep Behavior Disorder/genetics

KW - Synucleinopathies/genetics

KW - HLA-DRB1 Chains/genetics

KW - HLA Antigens

U2 - 10.1002/acn3.51841

DO - 10.1002/acn3.51841

M3 - Article

C2 - 37401389

SN - 2328-9503

VL - 10

SP - 1682

EP - 1687

JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

IS - 9

ER -

HLA in isolated REM sleep behavior disorder and Lewy body dementia

Abstract

Keywords

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