TY - JOUR
T1 - HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics
AU - Abecasis, Ana B.
AU - Wensing, Annemarie M.J.
AU - Paraskevis, Dimitris
AU - Vercauteren, Jurgen
AU - Theys, Kristof
AU - Van de Vijver, David A.M.C.
AU - Albert, Jan
AU - Asjö, Birgitta
AU - Balotta, Claudia
AU - Beshkov, Danail
AU - Camacho, Ricardo J.
AU - Clotet, Bonaventura
AU - De Gascun, Cillian
AU - Griskevicius, Algis
AU - Grossman, Zehava
AU - Hamouda, Osamah
AU - Horban, Andrzej
AU - Kolupajeva, Tatjana
AU - Korn, Klaus
AU - Kostrikis, Leon G.
AU - Kücherer, Claudia
AU - Liitsola, Kirsi
AU - Linka, Marek
AU - Nielsen, Claus
AU - Otelea, Dan
AU - Paredes, Roger
AU - Poljak, Mario
AU - Puchhammer-Stöckl, Elisabeth
AU - Schmit, Jean Claude
AU - Sönnerborg, Anders
AU - Stanekova, Danika
AU - Stanojevic, Maja
AU - Struck, Daniel
AU - Boucher, Charles A.B.
AU - Vandamme, Anne Mieke
N1 - Funding Information:
The overall work has been partially funded by the European Commission (grant QLK2-CT-2001-01344, fifth framework; grant LSHP-CT-2006-518211, sixth framework). Investigators have been funded by: Fundação para a Ciência e Tecnologia (Portugal grant no. SFRH / BPD / 65605 / 2009), Research Fund (PDM) of the KU Leuven, Belgian AIDS Reference Laboratory Fund, Belgian Fonds voor Wetenschappelijk Onderzoek Vlaanderen (W.F.O. grant G.0611.09); Interuniversitaire Attractiepolen (Belgium; grant P6/41); Cyprus Research Promotion Foundation (grant Health/0104/22); Danish AIDS Foundation; Federal Ministry of Health (Germany; grant 1502-686-18); Federal Ministry of Education and Research (Germany; grant 01KI501); Fifth National Program on HIV/AIDS, Istituto Superiore di Sanità (Italy; grants N 40F.56 and 20D.1.6); Fondation Recherche sur le SiDA; Ministry of Health (Luxembourg); Ministry of Education and Science (Republic of Serbia; grant 175024); Slovak Ministry of Health ( Bratislava, grant 2005/37-SZU-15); Swedish Research Council; Maraton TV3 Fundation (Spain; grant 02–1730) and Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN, grant Health-F3-2009-223131, European Community’s Seventh Framework Programme FP7/ 2007–2013). Publications costs have been supported by Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN, grant Health-F3-2009-223131, European Community’s Seventh Framework Programme FP7/ 2007–2013).
PY - 2013/1/14
Y1 - 2013/1/14
N2 - Background: Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates and transmission routes.Results: We investigated the subtype distribution of HIV-1 in Europe and Israel in a representative sample of patients diagnosed between 2002 and 2005 and related it to the demographic data available. 2793 PRO-RT sequences were subtyped either with the REGA Subtyping tool or by a manual procedure that included phylogenetic tree and recombination analysis. The most prevalent subtypes/CRFs in our dataset were subtype B (66.1%), followed by sub-subtype A1 (6.9%), subtype C (6.8%) and CRF02_AG (4.7%). Substantial differences in the proportion of new diagnoses with distinct subtypes were found between European countries: the lowest proportion of subtype B was found in Israel (27.9%) and Portugal (39.2%), while the highest was observed in Poland (96.2%) and Slovenia (93.6%). Other subtypes were significantly more diagnosed in immigrant populations. Subtype B was significantly more diagnosed in men than in women and in MSM > IDUs > heterosexuals. Furthermore, the subtype distribution according to continent of origin of the patients suggests they acquired their infection there or in Europe from compatriots.Conclusions: The association of subtype with demographic parameters suggests highly compartmentalized epidemics, determined by social and behavioural characteristics of the patients.
AB - Background: Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates and transmission routes.Results: We investigated the subtype distribution of HIV-1 in Europe and Israel in a representative sample of patients diagnosed between 2002 and 2005 and related it to the demographic data available. 2793 PRO-RT sequences were subtyped either with the REGA Subtyping tool or by a manual procedure that included phylogenetic tree and recombination analysis. The most prevalent subtypes/CRFs in our dataset were subtype B (66.1%), followed by sub-subtype A1 (6.9%), subtype C (6.8%) and CRF02_AG (4.7%). Substantial differences in the proportion of new diagnoses with distinct subtypes were found between European countries: the lowest proportion of subtype B was found in Israel (27.9%) and Portugal (39.2%), while the highest was observed in Poland (96.2%) and Slovenia (93.6%). Other subtypes were significantly more diagnosed in immigrant populations. Subtype B was significantly more diagnosed in men than in women and in MSM > IDUs > heterosexuals. Furthermore, the subtype distribution according to continent of origin of the patients suggests they acquired their infection there or in Europe from compatriots.Conclusions: The association of subtype with demographic parameters suggests highly compartmentalized epidemics, determined by social and behavioural characteristics of the patients.
UR - http://www.scopus.com/inward/record.url?scp=84872127915&partnerID=8YFLogxK
U2 - 10.1186/1742-4690-10-7
DO - 10.1186/1742-4690-10-7
M3 - Article
C2 - 23317093
AN - SCOPUS:84872127915
SN - 1742-4690
VL - 10
JO - Retrovirology
JF - Retrovirology
IS - 1
M1 - 7
ER -