Histone deacetylase 6 in health and disease

Carole Seidel; Michael Schnekenburger; Mario Dicato; Marc Diederich

doi:10.2217/epi.14.69

Histone deacetylase 6 in health and disease

Carole Seidel, Michael Schnekenburger, Mario Dicato, Marc Diederich^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

184 Citations (Scopus)

Abstract

Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, and is involved in protein trafficking and degradation, cell shape and migration. Consequently, deregulation of HDAC6 activity was associated to a variety of diseases including cancer, neurodegenerative diseases and pathological autoimmune response. Therefore, HDAC6 represents an interesting potential therapeutic target. In this review, we discuss structural features of this histone deacetylase, regulation of its expression and activity, biological functions, implication in human disease initiation and progression. Finally will describe novel and selective HDAC6 inhibitors.

Original language	English
Pages (from-to)	103-118
Number of pages	16
Journal	Epigenomics
Volume	7
Issue number	1
DOIs	https://doi.org/10.2217/epi.14.69
Publication status	Published - 1 Feb 2015
Externally published	Yes

Keywords

HDAC6
HDAC6 inhibitor
autoimmune response
cancer
epigenetics
histone deacetylase
neurodegenerative disease

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10.2217/epi.14.69

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abstract = "Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, and is involved in protein trafficking and degradation, cell shape and migration. Consequently, deregulation of HDAC6 activity was associated to a variety of diseases including cancer, neurodegenerative diseases and pathological autoimmune response. Therefore, HDAC6 represents an interesting potential therapeutic target. In this review, we discuss structural features of this histone deacetylase, regulation of its expression and activity, biological functions, implication in human disease initiation and progression. Finally will describe novel and selective HDAC6 inhibitors.",

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AU - Seidel, Carole

AU - Schnekenburger, Michael

AU - Dicato, Mario

AU - Diederich, Marc

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AB - Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, and is involved in protein trafficking and degradation, cell shape and migration. Consequently, deregulation of HDAC6 activity was associated to a variety of diseases including cancer, neurodegenerative diseases and pathological autoimmune response. Therefore, HDAC6 represents an interesting potential therapeutic target. In this review, we discuss structural features of this histone deacetylase, regulation of its expression and activity, biological functions, implication in human disease initiation and progression. Finally will describe novel and selective HDAC6 inhibitors.

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KW - HDAC6 inhibitor

KW - autoimmune response

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KW - epigenetics

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Histone deacetylase 6 in health and disease

Abstract

Keywords

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