High pathogenic avian influenza A(H5) viruses of clade 2.3.4.4b in Europe - Why trends of virus evolution are more difficult to predict

Alice Fusaro*, Bianca Zecchin, Edoardo Giussani, Elisa Palumbo, Montserrat Agüero-García, Claudia Bachofen, Ádám Bálint, Fereshteh Banihashem, Ashley C. Banyard, Nancy Beerens, Manon Bourg, Francois Xavier Briand, Caroline Bröjer, Ian H. Brown, Brigitte Brugger, Alexander M.P. Byrne, Armend Cana, Vasiliki Christodoulou, Zuzana Dirbakova, Teresa FagulhaRon A.M. Fouchier, Laura Garza-Cuartero, George Georgiades, Britt Gjerset, Beatrice Grasland, Oxana Groza, Timm Harder, Ana Margarida Henriques, Charlotte Kristiane Hjulsager, Emiliya Ivanova, Zygimantas Janeliunas, Laura Krivko, Ken Lemon, Yuan Liang, Aldin Lika, Peter Malik, Michael J. Mcmenamy, Alexander Nagy, Imbi Nurmoja, Iuliana Onita, Anne Pohlmann, Sandra Revilla-Fernández, Azucena Sánchez-Sánchez, Vladimir Savic, Brigita Slavec, Krzysztof Smietanka, Chantal J. Snoeck, Mieke Steensels, Vilhjálmur Svansson, Edyta Swieton, Niina Tammiranta, Martin Tinak, Steven Van Borm, Siamak Zohari, Cornelia Adlhoch, Francesca Baldinelli, Calogero Terregino, Isabella Monne

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Since 2016, A(H5Nx) high pathogenic avian influenza (HPAI) virus of clade 2.3.4.4b has become one of the most serious global threats not only to wild and domestic birds, but also to public health. In recent years, important changes in the ecology, epidemiology, and evolution of this virus have been reported, with an unprecedented global diffusion and variety of affected birds and mammalian species. After the two consecutive and devastating epidemic waves in Europe in 2020-2021 and 2021-2022, with the second one recognized as one of the largest epidemics recorded so far, this clade has begun to circulate endemically in European wild bird populations. This study used the complete genomes of 1,956 European HPAI A(H5Nx) viruses to investigate the virus evolution during this varying epidemiological outline. We investigated the spatiotemporal patterns of A(H5Nx) virus diffusion to/from and within Europe during the 2020-2021 and 2021-2022 epidemic waves, providing evidence of ongoing changes in transmission dynamics and disease epidemiology. We demonstrated the high genetic diversity of the circulating viruses, which have undergone frequent reassortment events, providing for the first time a complete overview and a proposed nomenclature of the multiple genotypes circulating in Europe in 2020-2022. We described the emergence of a new genotype with gull adapted genes, which offered the virus the opportunity to occupy new ecological niches, driving the disease endemicity in the European wild bird population. The high propensity of the virus for reassortment, its jumps to a progressively wider number of host species, including mammals, and the rapid acquisition of adaptive mutations make the trend of virus evolution and spread difficult to predict in this unfailing evolving scenario.

Original languageEnglish
Article numberveae027
JournalVirus Evolution
Volume10
Issue number1
DOIs
Publication statusPublished - 6 Apr 2024

Keywords

  • Europe
  • high pathogenic avian influenza A(H5) viruses
  • phylodynamics
  • reassortments
  • spatial spread

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