High genetic diversity including potential new subtypes of hepatitis C virus genotype 6 in Lao People's Democratic Republic

J. M. Hübschen; P. Jutavijittum; T. Thammavong; B. Samountry; A. Yousukh; K. Toriyama; A. Sausy; C. P. Muller

doi:10.1111/j.1469-0691.2011.03665.x

High genetic diversity including potential new subtypes of hepatitis C virus genotype 6 in Lao People's Democratic Republic

J. M. Hübschen, P. Jutavijittum, T. Thammavong, B. Samountry, A. Yousukh, K. Toriyama, A. Sausy, C. P. Muller^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

33 Citations (Scopus)

Abstract

Sera from 105 anti-HCV-positive first-time blood donors collected in 2004, 2005 and 2008 in different provinces in Laos were investigated by PCR. Forty-five samples were positive for HCV (42.86%); two belonged to subtype 1b (2/45, 4.4%) and all others to genotype 6 (43/45, 95.6%), including subtypes 6b, 6h, 6k, 6l, 6n and 6q. Three groups of sequences were not clearly attributable to any genotype 6 subtype, two of which may be regarded as candidates for new subtypes of genotype 6. Two samples were mixed infected with different subtypes or clusters of genotype 6 viruses.

Original language	English
Pages (from-to)	E30-E34
Journal	Clinical Microbiology and Infection
Volume	17
Issue number	12
DOIs	https://doi.org/10.1111/j.1469-0691.2011.03665.x
Publication status	Published - Dec 2011

Keywords

Genotype
HCV
Laos
Phylogeny
Subtype

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10.1111/j.1469-0691.2011.03665.x

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title = "High genetic diversity including potential new subtypes of hepatitis C virus genotype 6 in Lao People's Democratic Republic",

abstract = "Sera from 105 anti-HCV-positive first-time blood donors collected in 2004, 2005 and 2008 in different provinces in Laos were investigated by PCR. Forty-five samples were positive for HCV (42.86%); two belonged to subtype 1b (2/45, 4.4%) and all others to genotype 6 (43/45, 95.6%), including subtypes 6b, 6h, 6k, 6l, 6n and 6q. Three groups of sequences were not clearly attributable to any genotype 6 subtype, two of which may be regarded as candidates for new subtypes of genotype 6. Two samples were mixed infected with different subtypes or clusters of genotype 6 viruses.",

keywords = "Genotype, HCV, Laos, Phylogeny, Subtype",

author = "H{\"u}bschen, {J. M.} and P. Jutavijittum and T. Thammavong and B. Samountry and A. Yousukh and K. Toriyama and A. Sausy and Muller, {C. P.}",

note = "Funding Information: The present study was financially supported by the Ministry of Cooperation of the Grand-Duchy of Luxembourg and by the Centre de Recherche Public—Sant{\'e}, Luxembourg. The authors declare that there is no conflict of interest related to the present manuscript.",

year = "2011",

month = dec,

doi = "10.1111/j.1469-0691.2011.03665.x",

language = "English",

volume = "17",

pages = "E30--E34",

journal = "Clinical Microbiology and Infection",

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TY - JOUR

T1 - High genetic diversity including potential new subtypes of hepatitis C virus genotype 6 in Lao People's Democratic Republic

AU - Hübschen, J. M.

AU - Jutavijittum, P.

AU - Thammavong, T.

AU - Samountry, B.

AU - Yousukh, A.

AU - Toriyama, K.

AU - Sausy, A.

AU - Muller, C. P.

N1 - Funding Information: The present study was financially supported by the Ministry of Cooperation of the Grand-Duchy of Luxembourg and by the Centre de Recherche Public—Santé, Luxembourg. The authors declare that there is no conflict of interest related to the present manuscript.

PY - 2011/12

Y1 - 2011/12

N2 - Sera from 105 anti-HCV-positive first-time blood donors collected in 2004, 2005 and 2008 in different provinces in Laos were investigated by PCR. Forty-five samples were positive for HCV (42.86%); two belonged to subtype 1b (2/45, 4.4%) and all others to genotype 6 (43/45, 95.6%), including subtypes 6b, 6h, 6k, 6l, 6n and 6q. Three groups of sequences were not clearly attributable to any genotype 6 subtype, two of which may be regarded as candidates for new subtypes of genotype 6. Two samples were mixed infected with different subtypes or clusters of genotype 6 viruses.

AB - Sera from 105 anti-HCV-positive first-time blood donors collected in 2004, 2005 and 2008 in different provinces in Laos were investigated by PCR. Forty-five samples were positive for HCV (42.86%); two belonged to subtype 1b (2/45, 4.4%) and all others to genotype 6 (43/45, 95.6%), including subtypes 6b, 6h, 6k, 6l, 6n and 6q. Three groups of sequences were not clearly attributable to any genotype 6 subtype, two of which may be regarded as candidates for new subtypes of genotype 6. Two samples were mixed infected with different subtypes or clusters of genotype 6 viruses.

KW - Genotype

KW - HCV

KW - Laos

KW - Phylogeny

KW - Subtype

UR - http://www.scopus.com/inward/record.url?scp=81255143347&partnerID=8YFLogxK

U2 - 10.1111/j.1469-0691.2011.03665.x

DO - 10.1111/j.1469-0691.2011.03665.x

M3 - Comment/debate

C2 - 21958219

AN - SCOPUS:81255143347

SN - 1198-743X

VL - 17

SP - E30-E34

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 12

ER -

High genetic diversity including potential new subtypes of hepatitis C virus genotype 6 in Lao People's Democratic Republic

Abstract

Keywords

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