High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia

Marina Wierz; Bassam Janji; Guy Berchem; Etienne Moussay; Jerome Paggetti

doi:10.1080/2162402X.2018.1465167

High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia

Marina Wierz
, Bassam Janji
, Guy Berchem
, Etienne Moussay^* (Main author)
, Jerome Paggetti

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

Abstract

In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.

Original language	English
Article number	e1465167
Journal	OncoImmunology
Volume	7
Issue number	8
DOIs	https://doi.org/10.1080/2162402X.2018.1465167
Publication status	Published - 3 Aug 2018

Keywords

chronic lymphocytic leukemia
immune-checkpoint blockade
immunotherapy
mass cytometry
tumor microenvironment

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10.1080/2162402X.2018.1465167

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title = "High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia",

abstract = "In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.",

keywords = "chronic lymphocytic leukemia, immune-checkpoint blockade, immunotherapy, mass cytometry, tumor microenvironment",

author = "Marina Wierz and Bassam Janji and Guy Berchem and Etienne Moussay and Jerome Paggetti",

note = "Funding Information: This work was supported by funding from Fonds National de la Recherche Luxembourg (FNR, INTER/DFG/11509946), Fonds de la Recherche Scientifique (FNRS, T?l?vie/7.4508.16) and from Luxembourg Institute of Health (HEMATEXO). Funding Information: This work was supported by funding from Fonds National de la Recherche Luxembourg (FNR, INTER/DFG/11509946), Fonds de la Recherche Scien-tifique (FNRS, T{\'e}l{\'e}vie/7.4508.16) and from Luxembourg Institute of Health (HEMATEXO). Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published with license by Taylor \& Francis Group, LLC. {\textcopyright} 2018, {\textcopyright} Marina Wierz, Bassam Janji, Guy Berchem, Etienne Moussay, and Jerome Paggetti.",

year = "2018",

month = aug,

day = "3",

doi = "10.1080/2162402X.2018.1465167",

language = "English",

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TY - JOUR

T1 - High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia

AU - Wierz, Marina

AU - Janji, Bassam

AU - Berchem, Guy

AU - Moussay, Etienne

AU - Paggetti, Jerome

N1 - Funding Information: This work was supported by funding from Fonds National de la Recherche Luxembourg (FNR, INTER/DFG/11509946), Fonds de la Recherche Scientifique (FNRS, T?l?vie/7.4508.16) and from Luxembourg Institute of Health (HEMATEXO). Funding Information: This work was supported by funding from Fonds National de la Recherche Luxembourg (FNR, INTER/DFG/11509946), Fonds de la Recherche Scien-tifique (FNRS, Télévie/7.4508.16) and from Luxembourg Institute of Health (HEMATEXO). Publisher Copyright: © 2018, © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2018, © Marina Wierz, Bassam Janji, Guy Berchem, Etienne Moussay, and Jerome Paggetti.

PY - 2018/8/3

Y1 - 2018/8/3

N2 - In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.

AB - In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.

KW - chronic lymphocytic leukemia

KW - immune-checkpoint blockade

KW - immunotherapy

KW - mass cytometry

KW - tumor microenvironment

UR - https://www.scopus.com/pages/publications/85047419899

U2 - 10.1080/2162402X.2018.1465167

DO - 10.1080/2162402X.2018.1465167

M3 - Article

C2 - 30221064

AN - SCOPUS:85047419899

SN - 2162-4011

VL - 7

JO - OncoImmunology

JF - OncoImmunology

IS - 8

M1 - e1465167

ER -

High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia

Abstract

Keywords

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