High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia

Marina Wierz, Bassam Janji, Guy Berchem, Etienne Moussay* (Main author), Jerome Paggetti

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.

Original languageEnglish
Article numbere1465167
JournalOncoImmunology
Volume7
Issue number8
DOIs
Publication statusPublished - 3 Aug 2018

Keywords

  • chronic lymphocytic leukemia
  • immune-checkpoint blockade
  • immunotherapy
  • mass cytometry
  • tumor microenvironment

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