@article{c5517e5676ca47499b64c4902533d413,
title = "High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia",
abstract = "In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.",
keywords = "chronic lymphocytic leukemia, immune-checkpoint blockade, immunotherapy, mass cytometry, tumor microenvironment",
author = "Marina Wierz and Bassam Janji and Guy Berchem and Etienne Moussay and Jerome Paggetti",
note = "Funding Information: This work was supported by funding from Fonds National de la Recherche Luxembourg (FNR, INTER/DFG/11509946), Fonds de la Recherche Scientifique (FNRS, T?l?vie/7.4508.16) and from Luxembourg Institute of Health (HEMATEXO). Funding Information: This work was supported by funding from Fonds National de la Recherche Luxembourg (FNR, INTER/DFG/11509946), Fonds de la Recherche Scien-tifique (FNRS, T{\'e}l{\'e}vie/7.4508.16) and from Luxembourg Institute of Health (HEMATEXO). Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2018, {\textcopyright} Marina Wierz, Bassam Janji, Guy Berchem, Etienne Moussay, and Jerome Paggetti.",
year = "2018",
month = aug,
day = "3",
doi = "10.1080/2162402X.2018.1465167",
language = "English",
volume = "7",
journal = "OncoImmunology",
issn = "2162-4011",
publisher = "Landes Bioscience",
number = "8",
}