High content screening and proteomic analysis identify a kinase inhibitor that rescues pathological phenotypes in a patient-derived model of Parkinson's disease

Keyphrases

• Patient-derived Models 100%
• Proteomic Analysis 100%
• Kinase Inhibitor 100%
• High-content Screening 100%
• Parkinson's Disease Model 100%
• Screening Analysis 100%
• BX795 100%
• Pathological Phenotype 100%
• Alpha-synuclein (α-syn) 66%
• Protein Synthesis 66%
• Protective Effect 33%
• Disease-associated 33%
• Idiopathic Parkinson's Disease 33%
• Neurodegeneration 33%
• Autophagy 33%
• Cell-based 33%
• Stress Response 33%
• Molecular Pathways 33%
• Neuronal Cells 33%
• Induced Pluripotent Stem Cells (iPSCs) 33%
• Small Molecules 33%
• Biological Processes 33%
• High-throughput Screening 33%
• Protein Clearance 33%
• Human Induced Pluripotent Stem Cell-derived Neurons 33%
• RNA Metabolism 33%
• Screening Approach 33%
• Proteomic Profiling 33%
• High-content Imaging 33%
• Screening Campaign 33%
• Disease Modeling 33%
• Protein Modification 33%
• Multikinase Inhibitor 33%
• Kinase Inhibitor Design 33%
• Signaling Hub 33%
• Neuroprotective Action 33%
• MTORC1 Pathway 33%
• Neurodegenerative Disorders 33%
• MTOR Signaling 33%
• Protein Transition 33%

Biochemistry, Genetics and Molecular Biology

• Induced Pluripotent Stem Cell 100%
• Protein Biosynthesis 100%
• Kinase 100%
• Phosphotransferase 100%
• Protein Kinase A 100%
• Proteomics 100%
• Synuclein 100%
• Small Molecule 50%
• Disease Modeling 50%
• Mediator 50%
• Biological Phenomena and Functions Concerning the Entire Organism 50%
• Autophagy 50%
• Single Drug Dose 50%
• High Throughput Screening 50%
• RNA Metabolism 50%