Heterotypic communication as the promoter of phenotypic plasticity of cancer cells: The role of cancer secretomes

André Zelanis*, Uilla Barcick, Nathália de Vasconcellos Racorti, Murilo Salardani

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cellular communication relies on signaling circuits whose statuses are mainly modulated by soluble biomolecules such as carbohydrates, lipids, proteins, and metabolites as well as extracellular vesicles (EVs). Therefore, the active secretion of such biomolecules is critical for both cell homeostasis and proper pathophysiological responses in a timely fashion. In this context, proteins are among the main modulators of such biological responses. Hence, profiling cell line secretomes may be an opportunity for the identification of “signatures” of specific cell types (i.e., stromal or metastatic cells) with important prognostic/therapeutic value. This review will focus on the biological implications of cell secretomes in the context of cancer, as well as their functional roles in shaping the tumoral microenvironment (TME) and communication status of participating cells.

Original languageEnglish
Article number2200243
JournalProteomics
Volume23
Issue number23-24
DOIs
Publication statusPublished - Dec 2023
Externally publishedYes

Keywords

  • animal proteomics
  • biology
  • biomarkers
  • biomedicine
  • body fluids
  • cancer
  • cell
  • cell biology
  • secretome

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