TY - JOUR
T1 - Hepatitis B virus infection assessed 3 to 18 years after vaccination in Cuban children and adolescents born to HBsAg-positive mothers
AU - Rodríguez Lay, Licel de los Angeles
AU - Bello Corredor, Marité
AU - Montalvo Villalba, Maria Caridad
AU - Chibás Ojeda, Annia Gertrudis
AU - Sariego Frómeta, Susel
AU - Diaz González, Manuel
AU - Abad Lamoth, Yoandra
AU - Sánchez Wong, Meilin
AU - Sausy, Aurélie
AU - Muller, Claude P.
AU - Hübschen, Judith M.
N1 - Funding Information:
The authors want to acknowledge Dr. Verena Muzio from the Center for Genetic Engineering and Biotechnology for her valuable comments. Also, the authors are grateful for the support of the Cuban Program for the Control and Prevention of hepatitis viruses. For the work done in Luxembourg we acknowledge the financial support of the Ministry of Foreign and European Affairs.
Publisher Copyright:
© 2017, Springer-Verlag Wien.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Thirty-two participants, aged between 3-18 years, born to hepatitis B surface antigen (HBsAg)-positive mothers and vaccinated at birth were analyzed for hepatitis B virus (HBV) infection. Overall, 56% had anti-HB titers ≥10 IU/L; five were positive for antibodies to the core antigen (anti-HBc), and two of these were also positive for HBsAg/DNA. One of the HBsAg/anti-HBc double-negative children presented with an unusual occult infection (HBV DNA-positive). No known vaccine escape mutations were detectable. Our data suggest that the vaccine protected 93.8% of children in this high-risk group against chronic HBV infection. Occult infections should be considered even in countries with low endemicity and high vaccination coverage.
AB - Thirty-two participants, aged between 3-18 years, born to hepatitis B surface antigen (HBsAg)-positive mothers and vaccinated at birth were analyzed for hepatitis B virus (HBV) infection. Overall, 56% had anti-HB titers ≥10 IU/L; five were positive for antibodies to the core antigen (anti-HBc), and two of these were also positive for HBsAg/DNA. One of the HBsAg/anti-HBc double-negative children presented with an unusual occult infection (HBV DNA-positive). No known vaccine escape mutations were detectable. Our data suggest that the vaccine protected 93.8% of children in this high-risk group against chronic HBV infection. Occult infections should be considered even in countries with low endemicity and high vaccination coverage.
KW - HBV vaccine escape mutants
KW - Occult HBV infection
KW - Post-vaccination serological testing
KW - Seroprotection
UR - https://www.scopus.com/pages/publications/85018829261
U2 - 10.1007/s00705-017-3365-6
DO - 10.1007/s00705-017-3365-6
M3 - Article
C2 - 28439708
AN - SCOPUS:85018829261
SN - 0304-8608
VL - 162
SP - 2393
EP - 2396
JO - Archives of Virology
JF - Archives of Virology
IS - 8
ER -