Hepatic energy metabolism in a family with a glucokinase gene mutation and dysglycemia

for the GDS study group

doi:10.1016/j.diabres.2022.109779

Hepatic energy metabolism in a family with a glucokinase gene mutation and dysglycemia

for the GDS study group

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

Carriers heterozygous for the D124N (c.370, GAC > AAC in exon 4) variant of GCK not only exhibit reduced insulin-secretion, but also impaired adipose insulin sensitivity, which may shift fatty acids towards the liver. This could contribute to increased hepatic lipid-accumulation and alterations of liver energy metabolism resulting in dysglycemia. ClinicalTrial.gov registration no: NCT01055093.

Original language	English
Article number	109779
Journal	Diabetes Research and Clinical Practice
Volume	185
DOIs	https://doi.org/10.1016/j.diabres.2022.109779
Publication status	Published - Mar 2022
Externally published	Yes

Keywords

Beta-cell function
Glucokinase
Hepatic energy metabolism
Insulin sensitivity
MODY

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10.1016/j.diabres.2022.109779

Cite this

@article{18250c3d84954581b05364610c3cc148,

title = "Hepatic energy metabolism in a family with a glucokinase gene mutation and dysglycemia",

abstract = "Carriers heterozygous for the D124N (c.370, GAC > AAC in exon 4) variant of GCK not only exhibit reduced insulin-secretion, but also impaired adipose insulin sensitivity, which may shift fatty acids towards the liver. This could contribute to increased hepatic lipid-accumulation and alterations of liver energy metabolism resulting in dysglycemia. ClinicalTrial.gov registration no: NCT01055093.",

keywords = "Beta-cell function, Glucokinase, Hepatic energy metabolism, Insulin sensitivity, MODY",

author = "K{\'a}lm{\'a}n B{\'o}dis and Birgit Knebel and Bettina Nowotny and Pavel Bobrov and Yuliya Kupriyanova and Zaharia, \{Oana Patricia\} and Yanislava Karusheva and Martin Sch{\"o}n and Martin Wolkersdorfer and Volker Burkart and Hadi Al-Hasani and Daniel Markgraf and Karsten M{\"u}ssig and Michael Roden and Julia Szendroedi and \{for the GDS study group\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = mar,

doi = "10.1016/j.diabres.2022.109779",

language = "English",

volume = "185",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Hepatic energy metabolism in a family with a glucokinase gene mutation and dysglycemia

AU - Bódis, Kálmán

AU - Knebel, Birgit

AU - Nowotny, Bettina

AU - Bobrov, Pavel

AU - Kupriyanova, Yuliya

AU - Zaharia, Oana Patricia

AU - Karusheva, Yanislava

AU - Schön, Martin

AU - Wolkersdorfer, Martin

AU - Burkart, Volker

AU - Al-Hasani, Hadi

AU - Markgraf, Daniel

AU - Müssig, Karsten

AU - Roden, Michael

AU - Szendroedi, Julia

AU - for the GDS study group

PY - 2022/3

Y1 - 2022/3

N2 - Carriers heterozygous for the D124N (c.370, GAC > AAC in exon 4) variant of GCK not only exhibit reduced insulin-secretion, but also impaired adipose insulin sensitivity, which may shift fatty acids towards the liver. This could contribute to increased hepatic lipid-accumulation and alterations of liver energy metabolism resulting in dysglycemia. ClinicalTrial.gov registration no: NCT01055093.

AB - Carriers heterozygous for the D124N (c.370, GAC > AAC in exon 4) variant of GCK not only exhibit reduced insulin-secretion, but also impaired adipose insulin sensitivity, which may shift fatty acids towards the liver. This could contribute to increased hepatic lipid-accumulation and alterations of liver energy metabolism resulting in dysglycemia. ClinicalTrial.gov registration no: NCT01055093.

KW - Beta-cell function

KW - Glucokinase

KW - Hepatic energy metabolism

KW - Insulin sensitivity

KW - MODY

UR - https://www.scopus.com/pages/publications/85125121801

U2 - 10.1016/j.diabres.2022.109779

DO - 10.1016/j.diabres.2022.109779

M3 - Article

C2 - 35176401

AN - SCOPUS:85125121801

SN - 0168-8227

VL - 185

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

M1 - 109779

ER -

Hepatic energy metabolism in a family with a glucokinase gene mutation and dysglycemia

Abstract

Keywords

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