TY - JOUR
T1 - Hematological malignancy-derived small extracellular vesicles and tumor microenvironment
T2 - The art of turning foes into friends
AU - Gargiulo, Ernesto
AU - Paggetti, Jerome
AU - Moussay, Etienne
N1 - This work was supported by grants from FNR Luxembourg (PRIDE15/10675146/CANBIO and INTER/DFG/16/11509946).
Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/5/27
Y1 - 2019/5/27
N2 - Small extracellular vesicles (small EVs) are commonly released by all cells, and are found in all body fluids. They are implicated in cell to cell short- and long-distance communication through the transfer of genetic material and proteins, as well as interactions between target cell membrane receptors and ligands anchored on small EV membrane. Beyond their canonical functions in healthy tissues, small EVs are strategically used by tumors to communicate with the cellular microenvironment and to establish a proper niche which would ultimately allow cancer cell proliferation, escape from the immune surveillance, and metastasis formation. In this review, we highlight the effects of hematological malignancy-derived small EVs on immune and stromal cells in the tumor microenvironment.
AB - Small extracellular vesicles (small EVs) are commonly released by all cells, and are found in all body fluids. They are implicated in cell to cell short- and long-distance communication through the transfer of genetic material and proteins, as well as interactions between target cell membrane receptors and ligands anchored on small EV membrane. Beyond their canonical functions in healthy tissues, small EVs are strategically used by tumors to communicate with the cellular microenvironment and to establish a proper niche which would ultimately allow cancer cell proliferation, escape from the immune surveillance, and metastasis formation. In this review, we highlight the effects of hematological malignancy-derived small EVs on immune and stromal cells in the tumor microenvironment.
KW - Exosomes
KW - Hematological malignancies
KW - Immunity
KW - Leukemia
KW - Lymphoma
KW - Myeloma
KW - Tumor microenvironment
KW - Tumor-derived small evs
UR - http://www.scopus.com/inward/record.url?scp=85083503859&partnerID=8YFLogxK
UR - https://www.ncbi.nlm.nih.gov/pubmed/31137912
U2 - 10.3390/cells8050511
DO - 10.3390/cells8050511
M3 - Review article
C2 - 31137912
SN - 2073-4409
VL - 8
JO - Cells
JF - Cells
IS - 5
M1 - 511
ER -