Hematologic parameters in pediatric uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa

Piero Olliaro*, Abdoulaye Djimdé, Grant Dorsey, Corine Karema, Andreas Mårtensson, Jean Louis Ndiaye, Sodiomon B. Sirima, Michel Vaillant, Julien Zwang

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    32 Citations (Scopus)

    Abstract

    Hematologic changes in acute and convalescent uncomplicated Plasmodium falciparum malaria have not been well studied, particularly in young children in Africa. Hematologic data were obtained for 3,044 children less than five years of age in seven randomized controlled trials at 14 sites. Using paired analysis between day 28 and baseline in patients without parasitologic failure as a proxy for malaria-induced effects, we found a statistically significant but clinically modest increase in leukocyte counts (5%) resulting from a larger increase in neutrophils (43%) than the decrease in lymphocytes counts (-16%); levels of hemoglobin and platelets decreased (-13% and -49%, respectively). Multivariate random effects analysis showed trends during follow-up (increased levels of hemoglobin, platelets and lymphocytes, and decreased levels of leukocytes and neutrophils) and identified explanatory variables. The risk of neutropenia increased with follow-up time independent of treatment outcome, and was lower with age, higher baseline parasitemia, and artemisinin combination treatment. These analyses provides information on hematologic variations caused by malaria.

    Original languageEnglish
    Pages (from-to)619-625
    Number of pages7
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume85
    Issue number4
    DOIs
    Publication statusPublished - Oct 2011

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