Heavy metal accumulation and metallothionein concentration in the frog Rana ridibunda after exposure to chromium or a mixture of chromium and cadmium

N. S. Loumbourdis*, Iason Kostaropoulos, Basiliki Theodoropoulou, Dimitra Kalmanti

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Abstract

The accumulation of two heavy metals (chromium (Cr) and cadmium (Cd)) in the liver, kidney and gut of Rana ridibunda exposed to Cr or to a mixture of Cr and Cd was investigated. The concentration of metallothioneins (MTs) in the same tissues was also studied. Both metals accumulated mainly in the kidney. Cr accumulation in the liver and gut was not affected by the presence of Cd. Furthermore, Cr concentration in the kidney was doubled when Cd was present. MT concentration did not increase after Cr treatment but it increased two- to six-fold over control values in mixture-exposed frogs, the highest value being observed in the gut. MTs in the gut could act as a barrier preventing ingested heavy metals from entering the blood stream. MT concentration correlated positively with Cd concentrations in both the liver and the gut of mixture-exposed animals.

Original languageEnglish
Pages (from-to)787-792
Number of pages6
JournalEnvironmental Pollution
Volume145
Issue number3
DOIs
Publication statusPublished - Feb 2007
Externally publishedYes

Keywords

  • Cadmium
  • Chromium
  • Detoxification
  • Frogs
  • Metallothioneins

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