Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells

Sabrina Fritah, Edwige Col, Cyril Boyault, Jérôme Govin, Karin Sadoul, Susanna Chiocca, Elisabeth Christians, Saadi Khochbin, Caroline Jolly, Claire Vourc'h*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)


A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.

Original languageEnglish
Pages (from-to)4976-4984
Number of pages9
JournalMolecular Biology of the Cell
Issue number23
Publication statusPublished - 2009
Externally publishedYes


Dive into the research topics of 'Heat-shock factor 1 controls genome-wide acetylation in heat-shocked cells'. Together they form a unique fingerprint.

Cite this