Abstract
Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit growth of different types of malignancies. Additionally, this multifaceted RTK inhibitor was reported to be a tumor suppressor, a stem cell regulator, and a modulator of different cellular phenotypes. This mini-review provides a concise and up-to-date summary about the known functions of LRIG1 and its related family members, with a special emphasis on underlying molecular mechanisms and the opportunities for harnessing its therapeutic potential against cancer.
Original language | English |
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Pages (from-to) | 109-116 |
Number of pages | 8 |
Journal | Biochimica et Biophysica Acta - Reviews on Cancer |
Volume | 1868 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Aug 2017 |
Keywords
- Cancer
- Ectodomain
- Leucine-rich repeats and immunoglobulin-like domains containing protein 1
- Nervous system
- Receptor tyrosine kinase