Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

Velma T.E. Aho; Zied Landoulsi; Rejko Krüger; Geeta Acharya; Gloria Aguayo; Myriam Alexandre; Wim Ammerlaan; Roxane Batutu; Katy Beaumont; Sibylle Béchet; Guy Berchem; Ibrahim Boussaad; Gessica Contesotto; Nancy De Bremaeker; Angelo Ferrari; Joëlle Fritz; Carlos Gamio; Manon Gantenbein; Laura Georges; Marijus Giraitis; Jérôme Graas; Anne Marie Hanff; Estelle Henry; Margaux Henry; Alexander Hundt; Sonja Jónsdóttir; Jochen Klucken; Olga Kofanova; Pauline Lambert; Ana Festas Lopes; Victoria Lorentz; Tainá M. Marques; Guilherme Marques; Deborah Mcintyre; Chouaib Mediouni; Alexia Mendibide; Myriam Menster; Michel Mittelbronn; Saïda Mtimet; Maeva Munsch; Ulf Nehrbass; Sarah Nickels; Fozia Noor; Claire Pauly; Laure Pauly; Lukas Pavelka; Magali Perquin; Achilleas Pexaras; Armin Rauschenberger; Lucie Remark; Ilsé Richard; Olivia Roland; Stefano Sapienza; Amir Sharify; Kate Sokolowska; Maud Theresine; Hermann Thien; Johanna Trouet; Michel Vaillant; Carlos Vega; Gelani Zelimkhanov; on behalf of the NCER-PD Consortium

doi:10.1038/s41531-024-00687-1

Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

Velma T.E. Aho^*, Zied Landoulsi, Rejko Krüger, Geeta Acharya, Gloria Aguayo, Myriam Alexandre, Wim Ammerlaan, Roxane Batutu, Katy Beaumont, Sibylle Béchet, Guy Berchem, Ibrahim Boussaad, Gessica Contesotto, Nancy De Bremaeker, Angelo Ferrari, Joëlle Fritz, Carlos Gamio, Manon Gantenbein, Laura Georges, Marijus GiraitisJérôme Graas, Anne Marie Hanff, Estelle Henry, Margaux Henry, Alexander Hundt, Sonja Jónsdóttir, Jochen Klucken, Olga Kofanova, Pauline Lambert, Ana Festas Lopes, Victoria Lorentz, Tainá M. Marques, Guilherme Marques, Deborah Mcintyre, Chouaib Mediouni, Alexia Mendibide, Myriam Menster, Michel Mittelbronn, Saïda Mtimet, Maeva Munsch, Ulf Nehrbass, Sarah Nickels, Fozia Noor, Claire Pauly, Laure Pauly, Lukas Pavelka, Magali Perquin, Achilleas Pexaras, Armin Rauschenberger, Lucie Remark, Ilsé Richard, Olivia Roland, Stefano Sapienza, Amir Sharify, Kate Sokolowska, Maud Theresine, Hermann Thien, Johanna Trouet, Michel Vaillant, Carlos Vega, Gelani Zelimkhanov, on behalf of the NCER-PD Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.

Original language	English
Article number	78
Journal	npj Parkinson's Disease
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41531-024-00687-1
Publication status	Published - 6 Apr 2024

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Aho, V. T. E., Landoulsi, Z., Krüger, R., Acharya, G., Aguayo, G., Alexandre, M., Ammerlaan, W., Batutu, R., Beaumont, K., Béchet, S., Berchem, G., Boussaad, I., Contesotto, G., De Bremaeker, N., Ferrari, A., Fritz, J., Gamio, C., Gantenbein, M., Georges, L., ... on behalf of the NCER-PD Consortium (2024). Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease. npj Parkinson's Disease, 10(1), Article 78. https://doi.org/10.1038/s41531-024-00687-1

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abstract = "Gut microbiome differences between people with Parkinson{\textquoteright}s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.",

author = "Aho, {Velma T.E.} and Zied Landoulsi and Rejko Kr{\"u}ger and Geeta Acharya and Gloria Aguayo and Myriam Alexandre and Wim Ammerlaan and Roxane Batutu and Katy Beaumont and Sibylle B{\'e}chet and Guy Berchem and Ibrahim Boussaad and Gessica Contesotto and {De Bremaeker}, Nancy and Angelo Ferrari and Jo{\"e}lle Fritz and Carlos Gamio and Manon Gantenbein and Laura Georges and Marijus Giraitis and J{\'e}r{\^o}me Graas and Hanff, {Anne Marie} and Estelle Henry and Margaux Henry and Alexander Hundt and Sonja J{\'o}nsd{\'o}ttir and Jochen Klucken and Olga Kofanova and Pauline Lambert and Lopes, {Ana Festas} and Victoria Lorentz and Marques, {Tain{\'a} M.} and Guilherme Marques and Deborah Mcintyre and Chouaib Mediouni and Alexia Mendibide and Myriam Menster and Michel Mittelbronn and Sa{\"i}da Mtimet and Maeva Munsch and Ulf Nehrbass and Sarah Nickels and Fozia Noor and Claire Pauly and Laure Pauly and Lukas Pavelka and Magali Perquin and Achilleas Pexaras and Armin Rauschenberger and Lucie Remark and Ils{\'e} Richard and Olivia Roland and Stefano Sapienza and Amir Sharify and Kate Sokolowska and Maud Theresine and Hermann Thien and Johanna Trouet and Michel Vaillant and Carlos Vega and Gelani Zelimkhanov and {on behalf of the NCER-PD Consortium}",

note = "Grant and Funding 863664/EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) Publisher Copyright: {\textcopyright} The Author(s) 2024.",

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doi = "10.1038/s41531-024-00687-1",

language = "English",

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Aho, VTE, Landoulsi, Z , Krüger, R , Acharya, G , Aguayo, G , Alexandre, M , Ammerlaan, W, Batutu, R, Beaumont, K , Béchet, S , Berchem, G , Boussaad, I , Contesotto, G, De Bremaeker, N, Ferrari, A , Fritz, J , Gamio, C , Gantenbein, M , Georges, L , Giraitis, M , Graas, J , Hanff, AM , Henry, E, Henry, M, Hundt, A , Jónsdóttir, S, Klucken, J, Kofanova, O , Lambert, P , Lopes, AF , Lorentz, V, Marques, TM, Marques, G, Mcintyre, D, Mediouni, C, Mendibide, A, Menster, M, Mittelbronn, M, Mtimet, S , Munsch, M, Nehrbass, U, Nickels, S, Noor, F , Pauly, C, Pauly, L, Pavelka, L , Perquin, M , Pexaras, A , Rauschenberger, A , Remark, L, Richard, I, Roland, O, Sapienza, S, Sharify, A, Sokolowska, K, Theresine, M , Thien, H , Trouet, J , Vaillant, M , Vega, C, Zelimkhanov, G & on behalf of the NCER-PD Consortium 2024, 'Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease', npj Parkinson's Disease, vol. 10, no. 1, 78. https://doi.org/10.1038/s41531-024-00687-1

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T1 - Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

AU - Aho, Velma T.E.

AU - Landoulsi, Zied

AU - Krüger, Rejko

AU - Acharya, Geeta

AU - Aguayo, Gloria

AU - Alexandre, Myriam

AU - Ammerlaan, Wim

AU - Batutu, Roxane

AU - Beaumont, Katy

AU - Béchet, Sibylle

AU - Berchem, Guy

AU - Boussaad, Ibrahim

AU - Contesotto, Gessica

AU - De Bremaeker, Nancy

AU - Ferrari, Angelo

AU - Fritz, Joëlle

AU - Gamio, Carlos

AU - Gantenbein, Manon

AU - Georges, Laura

AU - Giraitis, Marijus

AU - Graas, Jérôme

AU - Hanff, Anne Marie

AU - Henry, Estelle

AU - Henry, Margaux

AU - Hundt, Alexander

AU - Jónsdóttir, Sonja

AU - Klucken, Jochen

AU - Kofanova, Olga

AU - Lambert, Pauline

AU - Lopes, Ana Festas

AU - Lorentz, Victoria

AU - Marques, Tainá M.

AU - Marques, Guilherme

AU - Mcintyre, Deborah

AU - Mediouni, Chouaib

AU - Mendibide, Alexia

AU - Menster, Myriam

AU - Mittelbronn, Michel

AU - Mtimet, Saïda

AU - Munsch, Maeva

AU - Nehrbass, Ulf

AU - Nickels, Sarah

AU - Noor, Fozia

AU - Pauly, Claire

AU - Pauly, Laure

AU - Pavelka, Lukas

AU - Perquin, Magali

AU - Pexaras, Achilleas

AU - Rauschenberger, Armin

AU - Remark, Lucie

AU - Richard, Ilsé

AU - Roland, Olivia

AU - Sapienza, Stefano

AU - Sharify, Amir

AU - Sokolowska, Kate

AU - Theresine, Maud

AU - Thien, Hermann

AU - Trouet, Johanna

AU - Vaillant, Michel

AU - Vega, Carlos

AU - Zelimkhanov, Gelani

AU - on behalf of the NCER-PD Consortium

N1 - Grant and Funding 863664/EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) Publisher Copyright: © The Author(s) 2024.

PY - 2024/4/6

Y1 - 2024/4/6

N2 - Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.

AB - Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.

UR - http://www.scopus.com/inward/record.url?scp=85202152995&partnerID=8YFLogxK

U2 - 10.1038/s41531-024-00687-1

DO - 10.1038/s41531-024-00687-1

M3 - Article

C2 - 38582855

AN - SCOPUS:85202152995

SN - 2373-8057

VL - 10

JO - npj Parkinson's Disease

JF - npj Parkinson's Disease

IS - 1

M1 - 78

ER -

Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

Abstract

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