Glioma proteomics: Status and perspectives

Simone P. Niclou*, Fred Fack, Uros Rajcevic

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

59 Citations (Scopus)

Abstract

High grade gliomas are the most common brain tumors in adults and their malignant nature makes them the fourth biggest cause of cancer death. Major efforts in neuro-oncology research are needed to reach similar progress in treatment efficacy as that achieved for other cancers in recent years. In addition to the urgent need to identify novel effective drug targets against malignant gliomas, the search for glioma biomarkers and grade specific protein signatures will provide a much needed contribution to diagnosis, prognosis, treatment decision and assessment of treatment response. Over the past years glioma proteomics has been attempted at different levels, including proteome analysis of patient biopsies and bodily fluids, of glioma cell lines and animal models. Here we provide an extensive review of the outcome of these studies in terms of protein identifications (protein numbers and regulated proteins), with an emphasis on the methods used and the limitations of the studies with regard to biomarker discovery. This is followed by a perspective on novel technologies and on the potential future contribution of proteomics in a broad sense to understanding glioma biology.

Original languageEnglish
Pages (from-to)1823-1838
Number of pages16
JournalJournal of Proteomics
Volume73
Issue number10
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Astrocytoma
  • Biomarker
  • Brain tumor
  • Glioma
  • Mass spectrometry
  • Metabolomics
  • Proteome

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