@article{16bc3345c0fa4c5bbf42c28ca3c22021,
title = "Genotypic and antigenic characterization of hemagglutinin proteins of African measles virus isolates",
abstract = "A comprehensive phylogenetic study based on the hemagglutinin (H) protein of all known African measles virus (MV) isolates is presented. The study includes 64 new H gene sequences from Ghana, Nigeria and South Africa as well as viruses from Zambia and The Gambia for which only incomplete sequencing data were available and that have previously not been genotyped. The results provide further support to the tentative assignment of the Nigerian and Ghanaian viruses to a new genotype B3 within clade B. A distinct geographic distribution pattern emerged with clade B viruses circulating exclusively in African countries north of the equator. All MV strains from southern Africa grouped in clades A and D with the majority of viruses belonging to genotype D4. The viruses considerably differed by their sensitivity to neutralization by monoclonal antibodies (mAb), but three selected antibodies were sufficient to distinguish between African MVs representing four different genotypes. Copyright (C) 1999 Elsevier Science B.V.",
keywords = "Africa, Hemagglutinin, Measles virus, Monoclonal antibodies, Sequence",
author = "Truong, {Anh T.} and Stephanie Kreis and Wim Ammerlaan and Hartter, {Heike K.} and Festus Adu and Omilabu, {Sunday A.} and Oyefolu, {Akeeb O.} and Berbers, {Guy A.M.} and Muller, {Claude P.}",
note = "Funding Information: We gratefully acknowledge the support of the staff from the involved hospitals for collection of viruses: Dr Adekanle (St. Mary Hospital), Dr Kehinde (ASH Hospital), Dr Awodiji (LUTH), Dr Sanyaolu (MCH), Dr Omolaja (IDH), Mr Abayome, Mr Agunbiade and Mrs Oyodele (UCH). The Noguchi Memorial Institute was helpful in collecting viruses in Ghana, the Alexandra Health Clinic and the Rietfontein Hospital assisted in collecting viruses in South Africa. South African viruses were analyzed at the National Institute for Virology in Johannesburg, South Africa. We would also like to thank Frank Hanses for assistance with the computer analysis of H gene sequences. The financial support of the Centre de Recherche Public-Sant{\'e}, and the Minist{\`e}re des Affaires Etrang{\`e}res for the activities in Nigeria are gratefully acknowledged. A.T.T. was supported by a fellowship of the Minist{\`e}re de l{\textquoteright}Education Nationale (bourse R&D).",
year = "1999",
month = jul,
doi = "10.1016/S0168-1702(99)00072-6",
language = "English",
volume = "62",
pages = "89--95",
journal = "Virus Research",
issn = "0168-1702",
publisher = "Elsevier B.V.",
number = "1",
}