Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson disease

Nico Diederich*, Christiane Hilger, Christopher G. Goetz, Marc Keipes, François Hentges, Peter Vieregge, Henri Metz

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    44 Citations (Scopus)

    Abstract

    Genetic studies of the frequencies of mutant alleles for coding cytochrome P-450 monooxygenase (CYP 2D6) in Parkinson's disease (PD) patients have been inconsistent. We studied the mutants A and B in 80 strictly defined sporadic PD patients divided into young age onset of the disease (<40 years, N = 20), mid age onset (40-50 years, N = 12), and older age onset (>50 years, N = 48). They were compared with 108 controls from the same geographic area. There were no significant differences in allele or genotype frequencies between PD patients and controls. Future genetic studies in PD should focus on other alleles or other areas of the genome.

    Original languageEnglish
    Pages (from-to)463-465
    Number of pages3
    JournalAnnals of Neurology
    Volume40
    Issue number3
    DOIs
    Publication statusPublished - Sep 1996

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