TY - JOUR
T1 - Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson disease
AU - Diederich, Nico
AU - Hilger, Christiane
AU - Goetz, Christopher G.
AU - Keipes, Marc
AU - Hentges, François
AU - Vieregge, Peter
AU - Metz, Henri
PY - 1996/9
Y1 - 1996/9
N2 - Genetic studies of the frequencies of mutant alleles for coding cytochrome P-450 monooxygenase (CYP 2D6) in Parkinson's disease (PD) patients have been inconsistent. We studied the mutants A and B in 80 strictly defined sporadic PD patients divided into young age onset of the disease (<40 years, N = 20), mid age onset (40-50 years, N = 12), and older age onset (>50 years, N = 48). They were compared with 108 controls from the same geographic area. There were no significant differences in allele or genotype frequencies between PD patients and controls. Future genetic studies in PD should focus on other alleles or other areas of the genome.
AB - Genetic studies of the frequencies of mutant alleles for coding cytochrome P-450 monooxygenase (CYP 2D6) in Parkinson's disease (PD) patients have been inconsistent. We studied the mutants A and B in 80 strictly defined sporadic PD patients divided into young age onset of the disease (<40 years, N = 20), mid age onset (40-50 years, N = 12), and older age onset (>50 years, N = 48). They were compared with 108 controls from the same geographic area. There were no significant differences in allele or genotype frequencies between PD patients and controls. Future genetic studies in PD should focus on other alleles or other areas of the genome.
UR - http://www.scopus.com/inward/record.url?scp=0029835547&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/8797539
U2 - 10.1002/ana.410400319
DO - 10.1002/ana.410400319
M3 - Article
C2 - 8797539
AN - SCOPUS:0029835547
SN - 0364-5134
VL - 40
SP - 463
EP - 465
JO - Annals of Neurology
JF - Annals of Neurology
IS - 3
ER -