Genetic diversity of noroviruses from outbreaks, sporadic cases and wastewater in Luxembourg 2008-2009

J. R. Kremer; J. Langlet; S. Skraber; P. Weicherding; B. Weber; H. M. Cauchie; S. de Landtsheer; J. Even; C. P. Muller; L. Hoffmann; J. Mossong

doi:10.1111/j.1469-0691.2010.03407.x

Genetic diversity of noroviruses from outbreaks, sporadic cases and wastewater in Luxembourg 2008-2009

J. R. Kremer, J. Langlet, S. Skraber, P. Weicherding, B. Weber, H. M. Cauchie, S. de Landtsheer, J. Even, C. P. Muller, L. Hoffmann, J. Mossong^*

^*Corresponding author for this work

Department of Infection and Immunity

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Abstract

The genetic diversity of norovirus strains obtained from gastroenteritis outbreaks, sporadic case surveillance and wastewater plants was compared in Luxembourg from October 2008 until June 2009. Except for GI.6 and GIV.1 strains detected exclusively in wastewater, all other genotypes were also found in human samples. Of the nine NoV genotypes detected, only three (GII.4, GIIb/II.3 and GIIc/II.12) were associated with institutional outbreaks. The majority of sequences from all sources belonged to genotype GII.4, including two potentially new subvariants. Strains collected in the context of outbreaks may significantly under-represent the overall genetic diversity of NoVs circulating in a country.

Original language	English
Pages (from-to)	1173-1176
Number of pages	4
Journal	Clinical Microbiology and Infection
Volume	17
Issue number	8
DOIs	https://doi.org/10.1111/j.1469-0691.2010.03407.x
Publication status	Published - Aug 2011

Keywords

Genetic diversity
Luxembourg
Norovirus
Nursing homes
Sporadic cases
Surveillance
Wastewater

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10.1111/j.1469-0691.2010.03407.x

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Kremer, J. R., Langlet, J., Skraber, S., Weicherding, P., Weber, B., Cauchie, H. M., de Landtsheer, S., Even, J., Muller, C. P., Hoffmann, L., & Mossong, J. (2011). Genetic diversity of noroviruses from outbreaks, sporadic cases and wastewater in Luxembourg 2008-2009. Clinical Microbiology and Infection, 17(8), 1173-1176. https://doi.org/10.1111/j.1469-0691.2010.03407.x

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title = "Genetic diversity of noroviruses from outbreaks, sporadic cases and wastewater in Luxembourg 2008-2009",

abstract = "The genetic diversity of norovirus strains obtained from gastroenteritis outbreaks, sporadic case surveillance and wastewater plants was compared in Luxembourg from October 2008 until June 2009. Except for GI.6 and GIV.1 strains detected exclusively in wastewater, all other genotypes were also found in human samples. Of the nine NoV genotypes detected, only three (GII.4, GIIb/II.3 and GIIc/II.12) were associated with institutional outbreaks. The majority of sequences from all sources belonged to genotype GII.4, including two potentially new subvariants. Strains collected in the context of outbreaks may significantly under-represent the overall genetic diversity of NoVs circulating in a country.",

keywords = "Genetic diversity, Luxembourg, Norovirus, Nursing homes, Sporadic cases, Surveillance, Wastewater",

author = "Kremer, {J. R.} and J. Langlet and S. Skraber and P. Weicherding and B. Weber and Cauchie, {H. M.} and {de Landtsheer}, S. and J. Even and Muller, {C. P.} and L. Hoffmann and J. Mossong",

note = "Funding Information: This study received financial support by the National Research Fund (FNR) in Luxembourg (grant FNR/SECAL/07/04/03). We acknowledge the help of the participating general practitioners of the sentinel surveillance and all collaborating staff in nursing homes and cr{\`e}ches. ",

year = "2011",

month = aug,

doi = "10.1111/j.1469-0691.2010.03407.x",

language = "English",

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AU - Kremer, J. R.

AU - Langlet, J.

AU - Skraber, S.

AU - Weicherding, P.

AU - Weber, B.

AU - Cauchie, H. M.

AU - de Landtsheer, S.

AU - Even, J.

AU - Muller, C. P.

AU - Hoffmann, L.

AU - Mossong, J.

N1 - Funding Information: This study received financial support by the National Research Fund (FNR) in Luxembourg (grant FNR/SECAL/07/04/03). We acknowledge the help of the participating general practitioners of the sentinel surveillance and all collaborating staff in nursing homes and crèches.

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N2 - The genetic diversity of norovirus strains obtained from gastroenteritis outbreaks, sporadic case surveillance and wastewater plants was compared in Luxembourg from October 2008 until June 2009. Except for GI.6 and GIV.1 strains detected exclusively in wastewater, all other genotypes were also found in human samples. Of the nine NoV genotypes detected, only three (GII.4, GIIb/II.3 and GIIc/II.12) were associated with institutional outbreaks. The majority of sequences from all sources belonged to genotype GII.4, including two potentially new subvariants. Strains collected in the context of outbreaks may significantly under-represent the overall genetic diversity of NoVs circulating in a country.

AB - The genetic diversity of norovirus strains obtained from gastroenteritis outbreaks, sporadic case surveillance and wastewater plants was compared in Luxembourg from October 2008 until June 2009. Except for GI.6 and GIV.1 strains detected exclusively in wastewater, all other genotypes were also found in human samples. Of the nine NoV genotypes detected, only three (GII.4, GIIb/II.3 and GIIc/II.12) were associated with institutional outbreaks. The majority of sequences from all sources belonged to genotype GII.4, including two potentially new subvariants. Strains collected in the context of outbreaks may significantly under-represent the overall genetic diversity of NoVs circulating in a country.

KW - Genetic diversity

KW - Luxembourg

KW - Norovirus

KW - Nursing homes

KW - Sporadic cases

KW - Surveillance

KW - Wastewater

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JO - Clinical Microbiology and Infection

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IS - 8

ER -

Genetic diversity of noroviruses from outbreaks, sporadic cases and wastewater in Luxembourg 2008-2009

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Keywords

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