TY - JOUR
T1 - Genetic dissection of familial Parkinson's disease
AU - Riess, Olaf
AU - Jakes, Ross
AU - Krüger, Rejko
PY - 1998/10/1
Y1 - 1998/10/1
N2 - In the past few years, the genetic contribution to Parkinson's disease (PD) has gained major attention and has resulted in the identification of the first mutant gene, called α-synuclein, involved in the pathogenesis of autosomal-dominant PD. α-Synuclein is a major component of Lewy bodies, which are a neuropathological feature of PD. Furthermore, deletions in the parkin gene have been identified as the primary cause in rare forms of autosomal-recessive juvenile PD. The elucidation of polygenic changes in the dopamine pathway, mitochondrial dysfunction, and metabolism of xenobiotics is now technically possible by means of association and genotype studies. The increasing knowledge of the pathogenesis of PD at a molecular level will have important implications for the development of individual therapeutic strategies to prevent disease progression.
AB - In the past few years, the genetic contribution to Parkinson's disease (PD) has gained major attention and has resulted in the identification of the first mutant gene, called α-synuclein, involved in the pathogenesis of autosomal-dominant PD. α-Synuclein is a major component of Lewy bodies, which are a neuropathological feature of PD. Furthermore, deletions in the parkin gene have been identified as the primary cause in rare forms of autosomal-recessive juvenile PD. The elucidation of polygenic changes in the dopamine pathway, mitochondrial dysfunction, and metabolism of xenobiotics is now technically possible by means of association and genotype studies. The increasing knowledge of the pathogenesis of PD at a molecular level will have important implications for the development of individual therapeutic strategies to prevent disease progression.
UR - http://www.scopus.com/inward/record.url?scp=0031668101&partnerID=8YFLogxK
U2 - 10.1016/S1357-4310(98)01343-4
DO - 10.1016/S1357-4310(98)01343-4
M3 - Review article
C2 - 9793932
AN - SCOPUS:0031668101
SN - 1471-4914
VL - 4
SP - 438
EP - 444
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 10
ER -