Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae

Sandrine E. Nsango; Luc Abate; Martine Thoma; Julien Pompon; Malou Fraiture; Annika Rademacher; Antoine Berry; Parfait H. Awono-Ambene; Elena A. Levashina; Isabelle Morlais

doi:10.1016/j.ijpara.2012.03.008

Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae

Sandrine E. Nsango
, Luc Abate
, Martine Thoma
, Julien Pompon
, Malou Fraiture
, Annika Rademacher
, Antoine Berry
, Parfait H. Awono-Ambene
, Elena A. Levashina^*
, Isabelle Morlais

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

42 Citations (Scopus)

Abstract

Mosquito infections with natural isolates of . Plasmodium falciparum are notoriously variable and pose a problem for reliable evaluation of efficiency of transmission-blocking agents for malaria control interventions. Here, we show that monoclonal . P. falciparum isolates produce higher parasite loads than mixed ones. Induction of the mosquito immune responses by wounding efficiently decreases . Plasmodium numbers in monoclonal infections but fails to do so in infections with two or more parasite genotypes. Our results point to the parasites genetic complexity as a potentially crucial component of mosquito-parasite interactions.

Original language	English
Pages (from-to)	589-595
Number of pages	7
Journal	International Journal for Parasitology
Volume	42
Issue number	6
DOIs	https://doi.org/10.1016/j.ijpara.2012.03.008
Publication status	Published - 15 May 2012
Externally published	Yes

Keywords

COI
Complement
Immunity
Malaria
Mosquito
Plasmodium
Vector biology

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10.1016/j.ijpara.2012.03.008

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title = "Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae",

abstract = "Mosquito infections with natural isolates of . Plasmodium falciparum are notoriously variable and pose a problem for reliable evaluation of efficiency of transmission-blocking agents for malaria control interventions. Here, we show that monoclonal . P. falciparum isolates produce higher parasite loads than mixed ones. Induction of the mosquito immune responses by wounding efficiently decreases . Plasmodium numbers in monoclonal infections but fails to do so in infections with two or more parasite genotypes. Our results point to the parasites genetic complexity as a potentially crucial component of mosquito-parasite interactions.",

keywords = "COI, Complement, Immunity, Malaria, Mosquito, Plasmodium, Vector biology",

author = "Nsango, \{Sandrine E.\} and Luc Abate and Martine Thoma and Julien Pompon and Malou Fraiture and Annika Rademacher and Antoine Berry and Awono-Ambene, \{Parfait H.\} and Levashina, \{Elena A.\} and Isabelle Morlais",

year = "2012",

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doi = "10.1016/j.ijpara.2012.03.008",

language = "English",

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journal = "International Journal for Parasitology",

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TY - JOUR

T1 - Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae

AU - Nsango, Sandrine E.

AU - Abate, Luc

AU - Thoma, Martine

AU - Pompon, Julien

AU - Fraiture, Malou

AU - Rademacher, Annika

AU - Berry, Antoine

AU - Awono-Ambene, Parfait H.

AU - Levashina, Elena A.

AU - Morlais, Isabelle

PY - 2012/5/15

Y1 - 2012/5/15

N2 - Mosquito infections with natural isolates of . Plasmodium falciparum are notoriously variable and pose a problem for reliable evaluation of efficiency of transmission-blocking agents for malaria control interventions. Here, we show that monoclonal . P. falciparum isolates produce higher parasite loads than mixed ones. Induction of the mosquito immune responses by wounding efficiently decreases . Plasmodium numbers in monoclonal infections but fails to do so in infections with two or more parasite genotypes. Our results point to the parasites genetic complexity as a potentially crucial component of mosquito-parasite interactions.

AB - Mosquito infections with natural isolates of . Plasmodium falciparum are notoriously variable and pose a problem for reliable evaluation of efficiency of transmission-blocking agents for malaria control interventions. Here, we show that monoclonal . P. falciparum isolates produce higher parasite loads than mixed ones. Induction of the mosquito immune responses by wounding efficiently decreases . Plasmodium numbers in monoclonal infections but fails to do so in infections with two or more parasite genotypes. Our results point to the parasites genetic complexity as a potentially crucial component of mosquito-parasite interactions.

KW - COI

KW - Complement

KW - Immunity

KW - Malaria

KW - Mosquito

KW - Plasmodium

KW - Vector biology

UR - https://www.scopus.com/pages/publications/84861682071

U2 - 10.1016/j.ijpara.2012.03.008

DO - 10.1016/j.ijpara.2012.03.008

M3 - Article

C2 - 22554991

AN - SCOPUS:84861682071

SN - 0020-7519

VL - 42

SP - 589

EP - 595

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 6

ER -

Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae

Abstract

Keywords

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