Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae

Sandrine E. Nsango; Luc Abate; Martine Thoma; Julien Pompon; Malou Fraiture; Annika Rademacher; Antoine Berry; Parfait H. Awono-Ambene; Elena A. Levashina; Isabelle Morlais

doi:10.1016/j.ijpara.2012.03.008

Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae

Sandrine E. Nsango, Luc Abate, Martine Thoma, Julien Pompon, Malou Fraiture, Annika Rademacher, Antoine Berry, Parfait H. Awono-Ambene, Elena A. Levashina^*, Isabelle Morlais

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

42 Citations (Scopus)

Abstract

Mosquito infections with natural isolates of . Plasmodium falciparum are notoriously variable and pose a problem for reliable evaluation of efficiency of transmission-blocking agents for malaria control interventions. Here, we show that monoclonal . P. falciparum isolates produce higher parasite loads than mixed ones. Induction of the mosquito immune responses by wounding efficiently decreases . Plasmodium numbers in monoclonal infections but fails to do so in infections with two or more parasite genotypes. Our results point to the parasites genetic complexity as a potentially crucial component of mosquito-parasite interactions.

Original language	English
Pages (from-to)	589-595
Number of pages	7
Journal	International Journal for Parasitology
Volume	42
Issue number	6
DOIs	https://doi.org/10.1016/j.ijpara.2012.03.008
Publication status	Published - 15 May 2012
Externally published	Yes

Keywords

COI
Complement
Immunity
Malaria
Mosquito
Plasmodium
Vector biology

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10.1016/j.ijpara.2012.03.008

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title = "Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae",

abstract = "Mosquito infections with natural isolates of . Plasmodium falciparum are notoriously variable and pose a problem for reliable evaluation of efficiency of transmission-blocking agents for malaria control interventions. Here, we show that monoclonal . P. falciparum isolates produce higher parasite loads than mixed ones. Induction of the mosquito immune responses by wounding efficiently decreases . Plasmodium numbers in monoclonal infections but fails to do so in infections with two or more parasite genotypes. Our results point to the parasites genetic complexity as a potentially crucial component of mosquito-parasite interactions.",

keywords = "COI, Complement, Immunity, Malaria, Mosquito, Plasmodium, Vector biology",

author = "Nsango, {Sandrine E.} and Luc Abate and Martine Thoma and Julien Pompon and Malou Fraiture and Annika Rademacher and Antoine Berry and Awono-Ambene, {Parfait H.} and Levashina, {Elena A.} and Isabelle Morlais",

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T1 - Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae

AU - Nsango, Sandrine E.

AU - Abate, Luc

AU - Thoma, Martine

AU - Pompon, Julien

AU - Fraiture, Malou

AU - Rademacher, Annika

AU - Berry, Antoine

AU - Awono-Ambene, Parfait H.

AU - Levashina, Elena A.

AU - Morlais, Isabelle

PY - 2012/5/15

Y1 - 2012/5/15

N2 - Mosquito infections with natural isolates of . Plasmodium falciparum are notoriously variable and pose a problem for reliable evaluation of efficiency of transmission-blocking agents for malaria control interventions. Here, we show that monoclonal . P. falciparum isolates produce higher parasite loads than mixed ones. Induction of the mosquito immune responses by wounding efficiently decreases . Plasmodium numbers in monoclonal infections but fails to do so in infections with two or more parasite genotypes. Our results point to the parasites genetic complexity as a potentially crucial component of mosquito-parasite interactions.

AB - Mosquito infections with natural isolates of . Plasmodium falciparum are notoriously variable and pose a problem for reliable evaluation of efficiency of transmission-blocking agents for malaria control interventions. Here, we show that monoclonal . P. falciparum isolates produce higher parasite loads than mixed ones. Induction of the mosquito immune responses by wounding efficiently decreases . Plasmodium numbers in monoclonal infections but fails to do so in infections with two or more parasite genotypes. Our results point to the parasites genetic complexity as a potentially crucial component of mosquito-parasite interactions.

KW - COI

KW - Complement

KW - Immunity

KW - Malaria

KW - Mosquito

KW - Plasmodium

KW - Vector biology

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M3 - Article

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JO - International Journal for Parasitology

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IS - 6

ER -

Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae

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Keywords

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