TY - JOUR
T1 - Genetic causes of Parkinson's disease
T2 - Extending the pathway
AU - Riess, O.
AU - Krüger, R.
AU - Hochstrasser, H.
AU - Soehn, A. S.
AU - Nuber, S.
AU - Franck, T.
AU - Berg, D.
PY - 2006
Y1 - 2006
N2 - The functional characterization of identified disease genes in monogenic forms of Parkinson's disease (PD) allows first insights into molecular pathways leading to neurodegeneration and dysfunction of the nigrostriatal system. There is increasing evidence that disturbance of the ubiquitin proteasome pathway is one important feature of this process underscoring the relevance of protein misfolding and accumulation in the neurodegenerative process of PD. Other genes are involved in mitochondrial homeostasis and still others link newly identified signalling pathways to the established paradigm of oxidative stress in PD. Additional factors are posttranslational modifications of key proteins such as phosphorylation. Also, molecular data support the role of altered iron metabolism in PD. Here we describe known genes and novel genetic susceptibility factors and define their role in neurodegeneration.
AB - The functional characterization of identified disease genes in monogenic forms of Parkinson's disease (PD) allows first insights into molecular pathways leading to neurodegeneration and dysfunction of the nigrostriatal system. There is increasing evidence that disturbance of the ubiquitin proteasome pathway is one important feature of this process underscoring the relevance of protein misfolding and accumulation in the neurodegenerative process of PD. Other genes are involved in mitochondrial homeostasis and still others link newly identified signalling pathways to the established paradigm of oxidative stress in PD. Additional factors are posttranslational modifications of key proteins such as phosphorylation. Also, molecular data support the role of altered iron metabolism in PD. Here we describe known genes and novel genetic susceptibility factors and define their role in neurodegeneration.
UR - http://www.scopus.com/inward/record.url?scp=33750299699&partnerID=8YFLogxK
U2 - 10.1007/978-3-211-45295-0_29
DO - 10.1007/978-3-211-45295-0_29
M3 - Article
C2 - 17017528
AN - SCOPUS:33750299699
SN - 0303-6995
SP - 181
EP - 189
JO - Journal of Neural Transmission, Supplement
JF - Journal of Neural Transmission, Supplement
IS - 70
ER -