Genetic analysis of immunomodulating factors in sporadic Parkinson's disease

R. Krüger; C. Hardt; F. Tschentscher; S. Jäckel; W. Kuhn; T. Müller; J. Werner; D. Woitalla; D. Berg; N. Kühnl; G. A. Fuchs; E. J.M. Santos; H. Przuntek; J. T. Epplen; L. Schöls; O. Riess

doi:10.1007/s007020070078

Genetic analysis of immunomodulating factors in sporadic Parkinson's disease

R. Krüger^*, C. Hardt, F. Tschentscher, S. Jäckel, W. Kuhn, T. Müller, J. Werner, D. Woitalla, D. Berg, N. Kühnl, G. A. Fuchs, E. J.M. Santos, H. Przuntek, J. T. Epplen, L. Schöls, O. Riess

^*Corresponding author for this work

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Abstract

Immunomodulating factors have been shown to play a role in the pathogenesis of Parkinson's disease (PD) by biochemical methods. In order to investigate functionally important genes of the tumor necrosis factor alpha (TNFα) pathway we studied the frequency of DNA polymorphisms in the interleukin 6 (IL6), the TNFα, and the TNFα receptor 1 (TNFR1) genes in 264 sporadic German PD patients and in 183 age and sex matched German healthy controls. Analyzing the TNFα-308 polymorphism we found heterozygous individuals carrying alleles 1 and 2 more frequently in patients with a relative risk of 1.56 (p = 0.046, p(c) = 0.13, χ² = 3.98). In contrast, the frequency of the B/2 haplotype described by the TNFR1 - 609 and TNFRI + 36 polymorphisms was significantly decreased in our PD patients group (p = 0.0097, p(c) = 0.048, χ² = 6.69) with a relative risk reduced to 0.52. Our results suggest an involvement of immunomodulating factors in the pathogenesis of sporadic PD as revealed by a molecular genetic approach.

Original language	English
Pages (from-to)	553-562
Number of pages	10
Journal	Journal of Neural Transmission
Volume	107
Issue number	5
DOIs	https://doi.org/10.1007/s007020070078
Publication status	Published - 2000
Externally published	Yes

Keywords

Factor alpha
Genetics
Immunomodulation
Parkinson's disease
Tumor necrosis

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10.1007/s007020070078

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Krüger, R., Hardt, C., Tschentscher, F., Jäckel, S., Kuhn, W., Müller, T., Werner, J., Woitalla, D., Berg, D., Kühnl, N., Fuchs, G. A., Santos, E. J. M., Przuntek, H., Epplen, J. T., Schöls, L., & Riess, O. (2000). Genetic analysis of immunomodulating factors in sporadic Parkinson's disease. Journal of Neural Transmission, 107(5), 553-562. https://doi.org/10.1007/s007020070078

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title = "Genetic analysis of immunomodulating factors in sporadic Parkinson's disease",

abstract = "Immunomodulating factors have been shown to play a role in the pathogenesis of Parkinson's disease (PD) by biochemical methods. In order to investigate functionally important genes of the tumor necrosis factor alpha (TNFα) pathway we studied the frequency of DNA polymorphisms in the interleukin 6 (IL6), the TNFα, and the TNFα receptor 1 (TNFR1) genes in 264 sporadic German PD patients and in 183 age and sex matched German healthy controls. Analyzing the TNFα-308 polymorphism we found heterozygous individuals carrying alleles 1 and 2 more frequently in patients with a relative risk of 1.56 (p = 0.046, p(c) = 0.13, χ2 = 3.98). In contrast, the frequency of the B/2 haplotype described by the TNFR1 - 609 and TNFRI + 36 polymorphisms was significantly decreased in our PD patients group (p = 0.0097, p(c) = 0.048, χ2 = 6.69) with a relative risk reduced to 0.52. Our results suggest an involvement of immunomodulating factors in the pathogenesis of sporadic PD as revealed by a molecular genetic approach.",

keywords = "Factor alpha, Genetics, Immunomodulation, Parkinson's disease, Tumor necrosis",

author = "R. Kr{\"u}ger and C. Hardt and F. Tschentscher and S. J{\"a}ckel and W. Kuhn and T. M{\"u}ller and J. Werner and D. Woitalla and D. Berg and N. K{\"u}hnl and Fuchs, {G. A.} and Santos, {E. J.M.} and H. Przuntek and Epplen, {J. T.} and L. Sch{\"o}ls and O. Riess",

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doi = "10.1007/s007020070078",

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Krüger, R, Hardt, C, Tschentscher, F, Jäckel, S, Kuhn, W, Müller, T, Werner, J, Woitalla, D, Berg, D, Kühnl, N, Fuchs, GA, Santos, EJM, Przuntek, H, Epplen, JT, Schöls, L & Riess, O 2000, 'Genetic analysis of immunomodulating factors in sporadic Parkinson's disease', Journal of Neural Transmission, vol. 107, no. 5, pp. 553-562. https://doi.org/10.1007/s007020070078

TY - JOUR

T1 - Genetic analysis of immunomodulating factors in sporadic Parkinson's disease

AU - Krüger, R.

AU - Hardt, C.

AU - Tschentscher, F.

AU - Jäckel, S.

AU - Kuhn, W.

AU - Müller, T.

AU - Werner, J.

AU - Woitalla, D.

AU - Berg, D.

AU - Kühnl, N.

AU - Fuchs, G. A.

AU - Santos, E. J.M.

AU - Przuntek, H.

AU - Epplen, J. T.

AU - Schöls, L.

AU - Riess, O.

PY - 2000

Y1 - 2000

N2 - Immunomodulating factors have been shown to play a role in the pathogenesis of Parkinson's disease (PD) by biochemical methods. In order to investigate functionally important genes of the tumor necrosis factor alpha (TNFα) pathway we studied the frequency of DNA polymorphisms in the interleukin 6 (IL6), the TNFα, and the TNFα receptor 1 (TNFR1) genes in 264 sporadic German PD patients and in 183 age and sex matched German healthy controls. Analyzing the TNFα-308 polymorphism we found heterozygous individuals carrying alleles 1 and 2 more frequently in patients with a relative risk of 1.56 (p = 0.046, p(c) = 0.13, χ2 = 3.98). In contrast, the frequency of the B/2 haplotype described by the TNFR1 - 609 and TNFRI + 36 polymorphisms was significantly decreased in our PD patients group (p = 0.0097, p(c) = 0.048, χ2 = 6.69) with a relative risk reduced to 0.52. Our results suggest an involvement of immunomodulating factors in the pathogenesis of sporadic PD as revealed by a molecular genetic approach.

AB - Immunomodulating factors have been shown to play a role in the pathogenesis of Parkinson's disease (PD) by biochemical methods. In order to investigate functionally important genes of the tumor necrosis factor alpha (TNFα) pathway we studied the frequency of DNA polymorphisms in the interleukin 6 (IL6), the TNFα, and the TNFα receptor 1 (TNFR1) genes in 264 sporadic German PD patients and in 183 age and sex matched German healthy controls. Analyzing the TNFα-308 polymorphism we found heterozygous individuals carrying alleles 1 and 2 more frequently in patients with a relative risk of 1.56 (p = 0.046, p(c) = 0.13, χ2 = 3.98). In contrast, the frequency of the B/2 haplotype described by the TNFR1 - 609 and TNFRI + 36 polymorphisms was significantly decreased in our PD patients group (p = 0.0097, p(c) = 0.048, χ2 = 6.69) with a relative risk reduced to 0.52. Our results suggest an involvement of immunomodulating factors in the pathogenesis of sporadic PD as revealed by a molecular genetic approach.

KW - Factor alpha

KW - Genetics

KW - Immunomodulation

KW - Parkinson's disease

KW - Tumor necrosis

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U2 - 10.1007/s007020070078

DO - 10.1007/s007020070078

M3 - Article

C2 - 11072751

AN - SCOPUS:0034116193

SN - 0300-9564

VL - 107

SP - 553

EP - 562

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 5

ER -

Genetic analysis of immunomodulating factors in sporadic Parkinson's disease

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