@article{59b9d12b9e4044b8874306c0d2cc75cc,
title = "Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson's disease patients carrying the heterozygous mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 gene encoding Miro1",
abstract = "Fibroblasts from two Parkinson's disease (PD) patients carrying either the heterozygous mutation c.815G > A (Miro1 p.R272Q) or c.1348C > T (Miro1 p.R450C) in the RHOT1 gene, were converted into induced pluripotent stem cells (iPSCs) using RNA-based and episomal reprogramming, respectively. The corresponding isogenic gene-corrected lines have been generated using CRISPR/Cas9 technology. These two isogenic pairs will be used to study Miro1-related molecular mechanisms underlying neurodegeneration in relevant iPSC-derived neuronal models (e.g., midbrain dopaminergic neurons and astrocytes).",
author = "Axel Chemla and Giuseppe Arena and Gizem Onal and Jonas Walter and Clara Berenguer-Escuder and Dajana Grossmann and Anne Gr{\"u}newald and Schwamborn, {Jens C.} and Rejko Kr{\"u}ger",
note = "Funding Information: AC is supported by the Luxembourg Fonds National de Recherche (FNR) within the framework of the PARK-QC DTU (PRIDE17/12244779/PARK-QC). Work of GA is supported by the FNR, grant number C21/BM/15850547/PINK1-DiaPDs. Work of AG was supported by the FNR within the ATTRACT program (Model-IPD, FNR9631103). RK obtained funding from the FNR PEARL Excellence Programme [FNR/P13/6682797], the Michael J. Fox Foundation, and the European Union's Horizon2020 research and innovation program (WIDESPREAD; CENTRE-PD; grant agreement no. 692320). In addition, RK, AG and GA were supported by the FNR CORE grant MiRisk-PD (C17/BM/11676395). Funding Information: AC is supported by the Luxembourg Fonds National de Recherche (FNR) within the framework of the PARK-QC DTU (PRIDE17/12244779/PARK-QC). Work of GA is supported by the FNR, grant number C21/BM/15850547/PINK1-DiaPDs. Work of AG was supported by the FNR within the ATTRACT program (Model-IPD, FNR9631103). RK obtained funding from the FNR PEARL Excellence Programme [FNR/P13/6682797], the Michael J. Fox Foundation , and the European Union{\textquoteright}s Horizon2020 research and innovation program (WIDESPREAD; CENTRE-PD ; grant agreement no. 692320 ). In addition, RK, AG and GA were supported by the FNR CORE grant MiRisk-PD ( C17/BM/11676395 ). Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
month = sep,
doi = "10.1016/j.scr.2023.103145",
language = "English",
volume = "71",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier B.V.",
}