Gene-environment interaction and Mendelian randomisation

P. Kolber, R. Krüger*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Genetic factors only account for up to a third of the cases of Parkinson's disease (PD), while the remaining cases are of unknown aetiology. Environmental exposures (such as pesticides or heavy metals) and the interaction with genetic susceptibility factors (summarized in the concept of impaired xenobiotic metabolism) are believed to play a major role in the mechanisms of neurodegeneration. Beside of the classical association studies (e.g. genome-wide association studies), a novel approach to investigate environmental risk factors are Mendelian randomisation studies. This review explores the gene-environment interaction and the gain of Mendelian randomisation studies in assessing causalities of modifiable risk factors for PD.

Original languageEnglish
Pages (from-to)597-603
Number of pages7
JournalRevue Neurologique
Issue number10
Publication statusPublished - Dec 2019


  • Gene-environment interaction
  • Genome-wide association studies (GWAS)
  • Mendelian randomisation
  • Parkinson's disease


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